Effect of nitric oxide synthase inhibition in experimental Pseudomonas keratitis in rabbits

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authorwosidÖzerol, İbrahim Halil/ABI-8015-2020
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorEr, H
dc.contributor.authorTurkoz, Y
dc.contributor.authorOzerol, IH
dc.contributor.authorUzmez, E
dc.date.accessioned2024-08-04T20:11:58Z
dc.date.available2024-08-04T20:11:58Z
dc.date.issued1998
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose. The aim of this study was to assess the efficacy of the nitric oxide synthase inhibitor L-NG-nitro-arginine-methyleser (L-NAME) in the treatment of experimental Pseudomonas keratitis. Methods. Twelve young New Zealand white rabbits were given intrastromal injections of Pseudomonas aeruginosa strains. Twenty-four hours later, the rabbits were randomly divided into four groups: group I was treated with topical 0.3% ciprofloxacin drops and a single subconjunctival injection of L-NAME (150 mg/kg); group 2 received topical 0.3% ciprofloxacin drops alone; group 3 received a single subconjunctival injection of L-NAME alone; group 4, the control group, was treated with topical balanced salt solution (BSS) drops. One drop of either ciprofloxacin of BSS was applied at each treatment interval. Twenty-six hours after the start of treatment, the eyes were examined by slit lamp to assess inflammation. Aqueous humor specimens were collected from each eye to measure the nitric oxide concentration. Corneas were removed to count bacteria results. Results. Slit lamp examination cell scores were significantly lower for groups 1 and 3 than groups 2 and 4 eyes (p = 0.002 to p = 0.004). No Viable bacteria were detected in the corneas of groups 1 and 2. Group 3 corneas had significantly fewer bacteria (6.33 +/- 0.42 x 10(3)) than group 4 (5.94 +/- 0.16 x 10(4)) (p < 0.05). Nitric oxide levels in the aqueous humor were significantly lower for group I eyes than for groups 2, 3, or 4 (p = 0.02, p = 0.01, and p = 0.003, respectively). Conclusions. We conclude that nitric oxide synthase inhibitors may be a useful adjunct but are not a replacement for traditional antibiotic drop therapy.en_US
dc.identifier.doi10.1177/112067219800800303
dc.identifier.endpage141en_US
dc.identifier.issn1120-6721
dc.identifier.issue3en_US
dc.identifier.pmid9793765en_US
dc.identifier.scopus2-s2.0-0031750660en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage137en_US
dc.identifier.urihttps://doi.org/10.1177/112067219800800303
dc.identifier.urihttps://hdl.handle.net/11616/93107
dc.identifier.volume8en_US
dc.identifier.wosWOS:000077895200003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWichtig Editoreen_US
dc.relation.ispartofEuropean Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectciprofloxacinen_US
dc.subjectkeratitisen_US
dc.subjectnitric oxideen_US
dc.subjectPseudomonasen_US
dc.subjectL-NAMEen_US
dc.titleEffect of nitric oxide synthase inhibition in experimental Pseudomonas keratitis in rabbitsen_US
dc.typeArticleen_US

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