Synthesis, structural characterization and anti-carcinogenic activity of new cyclotriphosphazenes containing dioxybiphenyl and chalcone groups

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dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridGORGULU, AHMET/0000-0002-7549-1524
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridKORAN, KENAN/0000-0002-2218-7211
dc.authoridOzen, Furkan/0000-0003-1178-1167
dc.authoridGorgulu, Ahmet Orhan/0000-0003-0632-4834
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidGörgülü, Ahmet Orhan/W-1964-2018
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.authorwosidGORGULU, AHMET/KBA-2787-2024
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidGörgülü, Ahmet Orhan/AAQ-4282-2021
dc.contributor.authorGorgulu, Ahmet Orhan
dc.contributor.authorKoran, Kenan
dc.contributor.authorOzen, Furkan
dc.contributor.authorTekin, Suat
dc.contributor.authorSandal, Suleyman
dc.date.accessioned2024-08-04T20:40:03Z
dc.date.available2024-08-04T20:40:03Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstract2,2-Dichloro-4,4,6,6-bis[spiro(2',2 ''-dioxy-1',1 ''-biphenylyl]cyclotriphosphazene (2) was synthesized from hexachlorocyclotriphosphazene (HCCP) and 2,2'-dihydroxybiphenyl. The mixed substituent chalcone/dioxybiphenyl cyclophosphazenes (2a-h) were obtained from the reactions of (2) with hydroxy chalcone compounds in K2CO3/acetone system. The chalcone-cyclophosphazene compounds were characterized by elemental analysis, FT-IR, H-1, C-13, P-31 NMR techniques. In vitro anti-carcinogenic activities of all compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MU) assay. Anti-carcinogenic activity of the compounds (2a-h) against androgen-dependent (LNCaP) and independent (PC-3) human prostate cancer cell lines were investigated. Our results indicate that the chalcone-phosphazene compounds (2a-h) have anti-carcinogenic activity on PC-3 and LNCaP cell lines (p < 0.05). The effective dose of the compounds was determined as 100 mu M. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipFirat Universityen_US
dc.description.sponsorshipFirat University would like to thank for their support.en_US
dc.identifier.doi10.1016/j.molstruc.2015.01.033
dc.identifier.endpage10en_US
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-84922534071en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2015.01.033
dc.identifier.urihttps://hdl.handle.net/11616/96683
dc.identifier.volume1087en_US
dc.identifier.wosWOS:000352748300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclotriphosphazeneen_US
dc.subjectChalcone-phosphazenesen_US
dc.subjectAnti-carcinogenic activityen_US
dc.subjectPC-3 and LNCaPen_US
dc.titleSynthesis, structural characterization and anti-carcinogenic activity of new cyclotriphosphazenes containing dioxybiphenyl and chalcone groupsen_US
dc.typeArticleen_US

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