Cytomegalovirus associated severe pneumonia in three liver transplant recipients

Basit Öğe Kaydı
dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridYalçınsoy, Murat/0000-0003-3407-7359
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridKose, Adem/0000-0002-1853-1243
dc.authoridBayindir, Yasar/0000-0003-3930-774X
dc.authoridOtlu, Baris/0000-0002-6220-0521
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidYalçınsoy, Murat/ABI-1421-2020
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidKose, Adem/AAD-1226-2020
dc.authorwosidBayindir, Yasar/T-1523-2017
dc.contributor.authorKose, Adem
dc.contributor.authorYalcinsoy, Murat
dc.contributor.authorSamdanci, Emine Turkmen
dc.contributor.authorBarut, Bora
dc.contributor.authorOtlu, Baris
dc.contributor.authorYilmaz, Sezai
dc.contributor.authorBayindir, Yasar
dc.date.accessioned2024-08-04T20:49:08Z
dc.date.available2024-08-04T20:49:08Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Cytomegalovirus (CMV), is the most common opportunistic infection, remains a cause of life-threatening disease and allograft rejection in liver transplant (LT) recipients. The purpose of this case series is to state that CMV may lead to severe pneumonia along with other bacteria. Methodology: CMV pneumonia was diagnosed with the thoracic computed tomography (CT) scan findings, bronchoscopic biopsy, real time quantitative Polymerase Chain Reaction (qPCR) and clinical symptoms. For extraction of CMV DNA from the clinical sample, EZ1 Virus Mini Kit v2.0 (Qiagen, Germany) was used, and aplification was performed with CMV QS-RGQ Kit (Qiagen, Germany) on Rotor Gene Q 5 Plex HMR (Qiagen, Germany) device. Results: All recipients had severe pneumonia, leukopenia, thrombocytopenia and at least two-fold increase in transaminases on seventh, twenty-eighth and twenty-second days after surgery, respectively. Thoracic CT scan revealed as diffuse interstitial infiltration in the lung parenchyma. Bronchoscopy, Gram-staining and culture from bronchoalveolar lavage (BAL) fluid were performed in all of them. During bronchoscopy, a bronchial biopsy was administered to two recipients. One recipient could not be performed procedure because of deep thrombocytopenia. PCR results were positive from serum and BAL fluid. Bronchial biopsy was compatible with CMV pneumonia. However, Pseudomonas aeruginosae was found in two cases and Klebsiella pneumoniae in one case BAL fluid cultures. Conclusions: CMV pneumonia can be seen simultaneously with bacterial agents due to the indirect effects of the CMV. It should be kept in mind that CMV pneumonia may cause severe clinical courses and can be mortal.en_US
dc.identifier.doi10.3855/jidc.12536
dc.identifier.endpage1343en_US
dc.identifier.issn1972-2680
dc.identifier.issue11en_US
dc.identifier.pmid33296349en_US
dc.identifier.scopus2-s2.0-85097916341en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1338en_US
dc.identifier.urihttps://doi.org/10.3855/jidc.12536
dc.identifier.urihttps://hdl.handle.net/11616/99679
dc.identifier.volume14en_US
dc.identifier.wosWOS:000711515100018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJ Infection Developing Countriesen_US
dc.relation.ispartofJournal of Infection in Developing Countriesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectliver transplantationen_US
dc.subjectcytomegalovirusen_US
dc.subjectpneumoniaen_US
dc.titleCytomegalovirus associated severe pneumonia in three liver transplant recipientsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu