Identification of viable myocardium in patients with chronic coronary artery disease and myocardial dysfunction: Comparison of low-dose dobutamine stress echocardiography and echocardiography during glucose-insulin-potassium infusion

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dc.authorwosidIleri, Mehmet/A-6525-2018
dc.contributor.authorYetkin, E
dc.contributor.authorSenen, K
dc.contributor.authorIleri, M
dc.contributor.authorAtak, R
dc.contributor.authorBattaoglu, B
dc.contributor.authorYetkin, O
dc.contributor.authorTandogan, I
dc.date.accessioned2024-08-04T20:13:10Z
dc.date.available2024-08-04T20:13:10Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractLow-dose dobutamine stress echocardiography (LDDSE) is one of the methods most used to assess myocardial viability. Glucose-insulin-potassium (GIK) has been shown to increase contraction of the ischernic zone. The aim of this study was to compare LDDSE and echocardiography during GIK infusion for detection of myocardial viability in patients with chronic coronary artery disease (CAD) and myocardial dysfunction. Twenty-one patients who had chronic CAD and myocardial dysfunction were included in the study. Glucose-insulin-potassium protocol consisted of a fixed dose of insulin (100 muU/kg/hour IV) and a variable glucose/potassium infusion rate. GIK echocardiography was made at baseline and after 60 minutes of GIK infusion. During continuous electrocardiographic, blood pressure, and echocardiographic monitoring, an intravenous infusion of dobutamine (3 mug/kg body weight/min) was started with an infusion pump and continued for 5 minutes and then increased to 5 mug/kg/min and 10 mug/kg/min for another 5 minutes. The detected viable myocardium was defined as I or 2 scores decreasing in at least 2 adjacent abnormal segments during LDDSE and GIK echocardiography. Viability was detected in 19% (52 segments) of the asynergic segments at baseline with GIK echocardiography and 16% (44 segments) of those segments with LDDSE (p > 0.05). Left ventricular wall motion score index at baseline was 2.24 +/- 0.35 and it decreased significantly during both LDDSE (p=0.004 vs 2.11 +/- 0.36) and GIK echocardiography (p=0.001 vs 2.09 +/- 0.32). The agreement between LDDSE and GIK echocardiography for detection of myocardial viability was 95%. This study shows that GIK echocardiography is similar to LDDSE for detection of myocardial viability. With the support of further clinical studies GIK echocardiography can be used to detect myocardial viability in patients with chronic CAD.en_US
dc.identifier.doi10.1177/000331970205300607
dc.identifier.endpage676en_US
dc.identifier.issn0003-3197
dc.identifier.issn1940-1574
dc.identifier.issue6en_US
dc.identifier.pmid12463620en_US
dc.identifier.scopus2-s2.0-0036846845en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage671en_US
dc.identifier.urihttps://doi.org/10.1177/000331970205300607
dc.identifier.urihttps://hdl.handle.net/11616/93449
dc.identifier.volume53en_US
dc.identifier.wosWOS:000179261600007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofAngiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeft-Ventricular Functionen_US
dc.subjectHibernating Myocardiumen_US
dc.subjectReversible Dysfunctionen_US
dc.subjectThrombolytic Therapyen_US
dc.subjectPredicts Recoveryen_US
dc.subjectIschemic-Hearten_US
dc.subjectFatty-Acidsen_US
dc.subjectBlood-Flowen_US
dc.subjectRevascularizationen_US
dc.subjectInfarctionen_US
dc.titleIdentification of viable myocardium in patients with chronic coronary artery disease and myocardial dysfunction: Comparison of low-dose dobutamine stress echocardiography and echocardiography during glucose-insulin-potassium infusionen_US
dc.typeArticleen_US

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