Myocardial ischemia-reperfusion in rats: reduction of infarct size by either supplemental physiological or pharmacological doses of melatonin

Basit Öğe Kaydı
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.contributor.authorSahna, E
dc.contributor.authorAcet, A
dc.contributor.authorOzer, MK
dc.contributor.authorOlmez, E
dc.date.accessioned2024-08-04T20:13:10Z
dc.date.available2024-08-04T20:13:10Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMyocardial ischemia reperfusion (I/R) represents a clinically relevant problem associated with thrombolysis, angioplasty and coronary bypass surgery. I/R injury is believed to be a consequence of free radical generation in the heart especially during the period of reperfusion. The pineal secretory product, melatonin, is known to be a potent free radical scavenger and pharmacological concentrations have been shown to reduce the I/R-induced cardiac damage in isolated rat hearts. However, the physiological role of melatonin in the prevention of this damage is unknown. Rats were pinealectomized or sham-operated (control) 2 months before the I/R studies. To produce cardiac damage, the left main coronary artery was occluded for 30 min, followed by 120 in reperfusion, in anesthetized rats. Infarct size, expressed as the percentage of the risk zone, was found significantly higher in pinealectomized rats (49 +/- 4%) than in the control group (34 +/- 6%). Melatonin administration (4 mg/kg, either before ischemia or reperfusion) to pinealectomized rats significantly reduced the infarct size values and returned the to the control values. On the other hand, melatonin administration (4 mg/kg) to sham-operated rats failed to attenuate significantly the I/R-induced infarct size. These results suggest that physiological melatonin concentrations are important in reducing the I/R-induced myocyte damage, while pharmacological concentrations of melatonin did not add to the beneficial effect. As melatonin levels have been reported to decrease with age, melatonin replacement therapy may attenuate I/R-induced myocardial injury, especially in older patients.en_US
dc.identifier.doi10.1034/j.1600-079X.2002.02924.x
dc.identifier.endpage238en_US
dc.identifier.issn0742-3098
dc.identifier.issn1600-079X
dc.identifier.issue4en_US
dc.identifier.pmid12390506en_US
dc.identifier.scopus2-s2.0-0036829769en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage234en_US
dc.identifier.urihttps://doi.org/10.1034/j.1600-079X.2002.02924.x
dc.identifier.urihttps://hdl.handle.net/11616/93447
dc.identifier.volume33en_US
dc.identifier.wosWOS:000178680400007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Pineal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectinfarct sizeen_US
dc.subjectmelatoninen_US
dc.subjectmyocardial ischemia-reperfusionen_US
dc.subjectpinealectomyen_US
dc.titleMyocardial ischemia-reperfusion in rats: reduction of infarct size by either supplemental physiological or pharmacological doses of melatoninen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu