Evaluation of Coronary Flow Level with Mots-C in Patients with STEMI Undergoing Primary PCI

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dc.authoridYaşar, Erdoğan/0000-0001-5882-3534
dc.authoridÇakmak, Tolga/0000-0002-4981-5521
dc.authoridYuksel, Furkan/0000-0002-1503-265X
dc.authorwosidYaşar, Erdoğan/GOH-1219-2022
dc.authorwosidÇakmak, Tolga/AAN-6803-2021
dc.authorwosidYuksel, Furkan/KHD-2785-2024
dc.contributor.authorCakmak, Tolga
dc.contributor.authorYasar, Erdogan
dc.contributor.authorCakmak, Esin
dc.contributor.authorTekin, Suat
dc.contributor.authorKarakus, Yasin
dc.contributor.authorTurkoglu, Caner
dc.contributor.authorYuksel, Furkan
dc.date.accessioned2024-08-04T20:53:21Z
dc.date.available2024-08-04T20:53:21Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The protective effects of mitochondrial open reading frame of the 12S rRNA-c (MOTS-C) on cardiovascular diseases have been shown in numerous studies. However, there is little documentation of the relationship between MOTS-C and coronary blood flow in ST-segment elevation myocardial infarction (STEMI). Objective: We aimed to investigate the role of MOTS-C, which is known to have cytoprotective properties in the pathogenesis of the no-reflow phenomenon, by comparing the coronary flow rate and MOTS-C levels in patients with STEMI submitted to primary PCI. Methods: 52 patients with STEMI and 42 patients without stenosis >50% in the coronary arteries were included in the study. The STEMI group was divided into two groups according to post-PCI TIMI (Thrombolysis In Myocardial Infarction) flow grade:(i) No-reflow: grade 0, 1, and 2 and (ii) grade 3(angiographic success). A p value of <0.05 was considered significant. Results: MOTS-C levels were significantly lower in the STEMI group compared to the control group (91.9 +/- 8.9 pg/mL vs. 171.8 +/- 12.5 pg/mL, p<0.001). In addition, the Receiver Operating Characteristics (ROC) curve analysis indicated that serum MOTS-C levels had a diagnostic value in predicting no-reflow (Area Under the ROC curve [AUC]:0.95, 95% CI:0.856-0.993, p<0.001). A MOTS-C >= 84.15 pg/mL measured at admission was shown to have 95.3% sensitivity and 88.9% specificity in predicting no-reflow. Conclusion: MOTS-C is a strong and independent predictor of no-reflow and in-hospital MACE in patients with STEMI. It was also noted that low MOTS-C levels may be an important prognostic marker of and may have a role in the pathogenesis of STEMI.en_US
dc.identifier.doi10.36660/abc.20220358
dc.identifier.issn0066-782X
dc.identifier.issn1678-4170
dc.identifier.issue1en_US
dc.identifier.pmid36629605en_US
dc.identifier.scopus2-s2.0-85146193402en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.36660/abc.20220358
dc.identifier.urihttps://hdl.handle.net/11616/101112
dc.identifier.volume120en_US
dc.identifier.wosWOS:000917483200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherArquivos Brasileiros Cardiologiaen_US
dc.relation.ispartofArquivos Brasileiros De Cardiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectST-elevation myocardial infarctionen_US
dc.subjectpercutaneous coronary interventionen_US
dc.subjectno-reflow phenomenonen_US
dc.subjectopen reading framesen_US
dc.titleEvaluation of Coronary Flow Level with Mots-C in Patients with STEMI Undergoing Primary PCIen_US
dc.typeArticleen_US

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