Food-induced anaphylaxis in early childhood and factors associated with its severity

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dc.authoridCulpan, Hazal Cansu/0000-0001-9244-3818
dc.authoridOzdemir, Cevdet/0000-0002-9284-4520
dc.authoridHizli Demirkale, Zeynep/0000-0001-6159-9895
dc.authoridYÜKSEL, Hasan/0000-0001-9577-8445
dc.authoridKiykim, Ayca/0000-0001-5821-3963
dc.authoridCekic, Sukru/0000-0002-9574-1842
dc.authoridORHAN, FAZIL/0000-0002-4850-932X
dc.authorwosidErdogan, Mehmet Sarper/AAC-2696-2020
dc.authorwosidCulpan, Hazal Cansu/AAA-5492-2020
dc.authorwosidTuncel, Tuba/GRO-3855-2022
dc.authorwosidOzdemir, Cevdet/X-5856-2018
dc.authorwosidÇöğürlü, Müjde Tuba/G-9730-2018
dc.authorwosidHizli Demirkale, Zeynep/AAU-4506-2020
dc.authorwosidOZDEMIR, ONER/KPB-3723-2024
dc.contributor.authorAydogan, Metin
dc.contributor.authorTopal, Erdem
dc.contributor.authorYakici, Nalan
dc.contributor.authorAcar, Hazal Cansu
dc.contributor.authorDemirkale, Zeynep Hizli
dc.contributor.authorArga, Mustafa
dc.contributor.authorUysal, Pinar
dc.date.accessioned2024-08-04T20:50:39Z
dc.date.available2024-08-04T20:50:39Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Several factors that increase the risk of severe food-induced anaphylaxis have been identified. Objective: We aimed to determine the demographic, etiologic, and clinical features of food-induced anaphylaxis in early childhood and also any other factors associated with severe anaphylaxis. Methods: We carried out a medical chart review of anaphylaxis cases from 16 pediatric allergy and immunology centers in Turkey. Results: The data of 227 patients with 266 food-induced anaphylaxis episodes were included in the study. The median (inter quartile range) age of the first anaphylaxis episode was 9 months (6-18 months); 160 of these patients were boys (70.5%). The anaphylaxis episodes were mild in 75 cases (28.2%), moderate in 154 cases (57.9%), and severe in 37 cases (13.9%). The most frequent food allergens involved were cow's milk (47.4%), nuts (16.7%), and hen's egg (15.8%). Epinephrine was administered in only 98 (36.8%) of these anaphylaxis episodes. A logistic regression analysis revealed two statistically significant factors that were independently associated with severe anaphylaxis: the presence of angioedema and hoarseness during the anaphylactic episode. Urticaria was observed less frequently in patients who developed hypotension. In addition, confusion and syncope were associated with 25.9- and 44.6-fold increases, respectively, in the risk of concomitant hypotension. Conclusion: Cow's milk, nuts, and hen's egg caused the majority of mild and moderate-to-severe anaphylaxis episodes. The presence of angioedema and hoarseness in any patient who presents with a history of food-induced anaphylaxis should alert clinicians that the reaction may be severe. In addition, the presence of confusion, syncope, or stridor probably indicates concomitant hypotension.en_US
dc.identifier.doi10.2500/aap.2021.42.210051
dc.identifier.endpageE144en_US
dc.identifier.issn1088-5412
dc.identifier.issn1539-6304
dc.identifier.issue5en_US
dc.identifier.pmid34474716en_US
dc.identifier.scopus2-s2.0-85114421078en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE135en_US
dc.identifier.urihttps://doi.org/10.2500/aap.2021.42.210051
dc.identifier.urihttps://hdl.handle.net/11616/100194
dc.identifier.volume42en_US
dc.identifier.wosWOS:000709183100002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOcean Side Publications Incen_US
dc.relation.ispartofAllergy and Asthma Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllergic Reactionsen_US
dc.subjectEuropean Academyen_US
dc.subjectChildrenen_US
dc.subjectPrevalenceen_US
dc.subjectEpinephrineen_US
dc.subjectMulticenteren_US
dc.titleFood-induced anaphylaxis in early childhood and factors associated with its severityen_US
dc.typeArticleen_US

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