The role of agomelatine in appetite regulation and body weight in rats

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dc.contributor.authorKorkmaz, Engin
dc.contributor.authorErden, Yavuz
dc.contributor.authorTekin, Cigdem
dc.contributor.authorTekin, Suat
dc.date.accessioned2026-04-04T13:33:19Z
dc.date.available2026-04-04T13:33:19Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractThe hypothalamic nuclei play a central role in the synthesis of anorexigenic and orexigenic neuropeptides, which are regulated by peripheral hormones, like leptin and ghrelin. Melatonergic receptors (MT1/MT2) are prominently expressed in the arcuate nucleus of the hypothalamus - an essential hub for appetite control - and in peripheral metabolic tissues where leptin and ghrelin are secreted. Agomelatine, an antidepressant drug and potent MT1/MT2 agonist, offers potential for modulating appetite. This study aimed to investigate the impact of agomelatine on appetite regulation. Forty male Sprague-Dawley rats were randomly allocated into four groups, control (no treatment), vehicle control, agomelatine 20 mg/kg (Ago-20), and agomelatine 40 mg/kg (Ago-40), and administered oral gavage for 14 days. Body weight and food intake were recorded daily. At the end of the experiment, rats were euthanized and blood and hypothalamic tissue samples were obtained. Agomelatine significantly reduced body weight (Ago-40: 275.2 +/- 7.2 g vs. control: 339.7 +/- 8.3 g, P < 0.05) and food intake (Ago-40: 20.21 +/- 1.32 g vs. control: 32.09 +/- 1.58 g, P < 0.05) by day 14, without affecting water intake. Plasma ghrelin levels decreased (Ago-40: 22.54 +/- 3.95 ng/dL vs. control: 46.67 +/- 4.84 ng/dL, P < 0.05), while leptin increased (Ago-40: 552.30 +/- 41.67 pg/mL vs. control: 271.10 +/- 32.12 pg/mL P < 0.05). Hypothalamic orexigenic neuropeptides neuropeptide Y (NPY) and agouti-related peptide (AgRP) were suppressed (NPY, Ago40: 0.61 +/- 0.02 vs. Control: 1.36 +/- 0.1321; AgRP, Ago40: 0.52 +/- 0.03 vs. Control: 1.49 +/- 0.27, P < 0.05), while anorexigenic cocaine- and amphetamine-regulated transcript (CART) and proopiomelanocortin (POMC) were elevated (CART: Ago40: 1.19 +/- 0.08 vs. Control: 0.92 +/- 0.06; POMC: Ago40: 1.49 +/- 0.17 vs. Control: 0.67 +/- 0.10, P < 0.05). These findings suggest agomelatine promotes weight loss by modulating appetite-related hormones and hypothalamic neuropeptides, highlighting its potential as a therapeutic for obesity and metabolic disorders.
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUEBITAK) [222S915]
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkiye (TUEBITAK),Grant/AwardNumber:222S915
dc.identifier.doi10.1113/EP092783
dc.identifier.issn0958-0670
dc.identifier.issn1469-445X
dc.identifier.orcid0000-0002-8365-2914
dc.identifier.pmid40801490
dc.identifier.scopus2-s2.0-105013090652
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1113/EP092783
dc.identifier.urihttps://hdl.handle.net/11616/109075
dc.identifier.wosWOS:001550611700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofExperimental Physiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectagomelatine
dc.subjectappetite
dc.subjectfood intake
dc.titleThe role of agomelatine in appetite regulation and body weight in rats
dc.typeArticle

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