Effect of caffeic acid phenethyl ester on survival of axial pattern flaps in rats with ischaemia-reperfusion injuries

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dc.contributor.authorBilen, BT
dc.contributor.authorKilinç, H
dc.contributor.authorAlaybeyoglu, N
dc.contributor.authorÇelik, M
dc.contributor.authorIraz, M
dc.contributor.authorSezgin, N
dc.contributor.authorGültek, A
dc.date.accessioned2024-08-04T20:15:21Z
dc.date.available2024-08-04T20:15:21Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOxygen-derived free radicals have been implicated in the pathogenesis of tissue injury after ischaemia-reperfusion. Caffeic acid phenethyl ester ( CAPE), an active ingredient of honeybee propolis, has been identified as having potent antioxidant and anti-inflammatory properties. We evaluated the ability of CAPE applied intraperitoneally in reducing tissue injury after ischaemia-reperfusion. To investigate whether treatment with CAPE modifies the concentrations of the endogenous indices of oxidant stress, we examined its effects on a model of flap ischaemia-reperfusion injury in rats. CAPE (10 mu mol/ kg) was given through the peritoneum before reperfusion. CAPE given intraperitoneally had an inhibitory effect on tissue injury after ischaemia-reperfusion comparable to that of a control group. The anti-inflammatory and antioxidant properties of CAPE may contribute to its suppression of tissue injury.en_US
dc.identifier.doi10.1080/02844310500443030
dc.identifier.endpage78en_US
dc.identifier.issn0284-4311
dc.identifier.issue2en_US
dc.identifier.pmid16537252en_US
dc.identifier.scopus2-s2.0-33645007883en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://doi.org/10.1080/02844310500443030
dc.identifier.urihttps://hdl.handle.net/11616/94315
dc.identifier.volume40en_US
dc.identifier.wosWOS:000235981200002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Asen_US
dc.relation.ispartofScandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectflapen_US
dc.subjectreperfusion injuryen_US
dc.subjectCAPEen_US
dc.titleEffect of caffeic acid phenethyl ester on survival of axial pattern flaps in rats with ischaemia-reperfusion injuriesen_US
dc.typeArticleen_US

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