Cytotoxic and antimicrobial potential of benzimidazole derivatives

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dc.authoridYesilada, Ozfer/0000-0003-0038-6575
dc.authoridKUCUKBAY, HASAN/0000-0002-7180-9486
dc.authorwosidYesilada, Ozfer/ABI-1335-2020
dc.authorwosidKUCUKBAY, HASAN/A-5050-2019
dc.contributor.authorKucukbay, Hasan
dc.contributor.authorUckun, Mustafa
dc.contributor.authorApohan, Elif
dc.contributor.authorYesilada, Ozfer
dc.date.accessioned2024-08-04T20:49:29Z
dc.date.available2024-08-04T20:49:29Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNew benzimidazole derivatives were synthesized and their structures were characterized by spectroscopic and microanalysis techniques. The cytotoxic properties of ten benzimidazole derivatives, five of which were synthesized in our previous studies, were determined against the lung cancer cell line, A549, and the healthy lung epithelial cell line, BEAS-2B. Among the ten compounds tested, based on the 72-h incubation results, compound 12 was the most cytotoxic against the A549 cell line, whereas against the BEAS-2B cell line, it was as cytotoxic as cisplatin. The IC50 values of compound 12 were 3.98 and 2.94 mu g/ml for A549 and BEAS-2B cells, respectively. The cisplatin values were 6.75 and 2.75 mu g/ml for A549 and BEAS-2B cells, respectively. Compounds 10, 8, 7, and 13 showed toxic effects against A549 cells, but were less toxic against BEAS-2B cells than cisplatin. The antimicrobial activity of these compounds against pathogenic bacteria and yeasts was also evaluated based on their minimum inhibitory concentration (MIC) values. The compounds, except 12 and 13, generally showed higher antimicrobial activity against yeasts, compared with bacteria. Compound 12 showed better activity against Pseudomonas aeruginosa and Staphylococcus aureus than against Escherichia coli. Compounds 7, 8, and 11 were the most effective ones against the microorganisms, and yeasts were highly sensitive to these compounds with MIC values of 25-100 mu g/ml.en_US
dc.description.sponsorshipInonu University, Malatya, Turkeyen_US
dc.description.sponsorshipThe authors acknowledge Inonu University, Malatya, Turkey, for financial support.en_US
dc.identifier.doi10.1002/ardp.202100076
dc.identifier.issn0365-6233
dc.identifier.issn1521-4184
dc.identifier.issue8en_US
dc.identifier.pmid33872394en_US
dc.identifier.scopus2-s2.0-85104392616en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/ardp.202100076
dc.identifier.urihttps://hdl.handle.net/11616/99888
dc.identifier.volume354en_US
dc.identifier.wosWOS:000641083900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofArchiv Der Pharmazieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectA549 cellsen_US
dc.subjectantimicrobial activityen_US
dc.subjectBEAS? 2B cellsen_US
dc.subjectbenzimidazole derivativesen_US
dc.subjectcytotoxicityen_US
dc.titleCytotoxic and antimicrobial potential of benzimidazole derivativesen_US
dc.typeArticleen_US

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