Effect of melatonin and atenolol on carbon monoxide cardiotoxicity

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dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authorwosidCelbiş, Osman/ABE-2803-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.contributor.authorMizrak, B
dc.contributor.authorCelbis, O
dc.contributor.authorParlakpinar, H
dc.contributor.authorÖlmez, E
dc.date.accessioned2024-08-04T20:15:26Z
dc.date.available2024-08-04T20:15:26Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to define the characteristics of heart rates and myocardial changes in rats exposed to carbon monoxide (CO), and the effects of reoxygenation, atenolol (a beta-blocker) and melatonin after sublethal CO intoxication. Widespread use of beta-blockers in cardiology practice and growing literature on the positive effect of melatonin in ischaemia reperfusion lead us to question their effects in case of CO intoxication. Rats were exposed to CO. After sublethal intoxication the rats were reoxygenated with ambient air. Subsequently blood values, electrocardiographic recordings and pathological changes were examined for each groups. Five rats died after CO intoxication in the control group: no myocardial changes were seen in light microscopy However, myocardium of seven reoxygenated rats presented contraction bands. Seven reoxygenated rats pretreated with atenotol had a higher number of contraction bands of myocardial cells. Seven reoxygenated rats pretreated with melatonin had more contraction bands than reoxygenated rats. and heart rate recordings of these animals revealed a profund and sustained bradycardia. Thus, melatonin and atenolol appear to have some adverse effects in CO intoxication on the myocardial cells.en_US
dc.identifier.doi10.1111/j.1742-7843.2006.pto_266.x
dc.identifier.endpage568en_US
dc.identifier.issn1742-7835
dc.identifier.issue6en_US
dc.identifier.pmid16700818en_US
dc.identifier.scopus2-s2.0-33646727621en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage565en_US
dc.identifier.urihttps://doi.org/10.1111/j.1742-7843.2006.pto_266.x
dc.identifier.urihttps://hdl.handle.net/11616/94384
dc.identifier.volume98en_US
dc.identifier.wosWOS:000237986500006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofBasic & Clinical Pharmacology & Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiovascular-Systemen_US
dc.subjectReleaseen_US
dc.subjectCellsen_US
dc.subjectPropranololen_US
dc.subjectReperfusionen_US
dc.subjectCalciumen_US
dc.titleEffect of melatonin and atenolol on carbon monoxide cardiotoxicityen_US
dc.typeArticleen_US

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