The Acute Effect of Humic Acid on Iron Accumulation in Rats

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dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridbilgic, yılmaz/0000-0002-2169-5548
dc.authoriderdogan, mehmet ali/0000-0002-1713-5695
dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridCagin, Yasir Furkan/0000-0002-2538-857X
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidbilgic, yılmaz/ABI-6432-2020
dc.authorwosiderdogan, mehmet ali/ABI-4675-2020
dc.authorwosidSeckin, Yuksel/ABI-3468-2020
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidCagin, Yasir Furkan/ABI-2709-2020
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.contributor.authorCagin, Yasir Furkan
dc.contributor.authorSahin, N.
dc.contributor.authorPolat, A.
dc.contributor.authorErdogan, M. A.
dc.contributor.authorAtayan, Y.
dc.contributor.authorEyol, E.
dc.contributor.authorBilgic, Y.
dc.date.accessioned2024-08-04T20:41:11Z
dc.date.available2024-08-04T20:41:11Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractFree iron leads to the formation of pro-oxidant reactive oxygen species (ROS). Humic acids (HAs) enhance permeability of cellular wall and act as a chelator through electron transferring. This study was designed to test chelator effect of HA on iron as well as its anti-oxidant effect against the iron-induced hepatotoxicity and cardiotoxicity. The rats used were randomly divided into four groups (n = 8/group): group I (the control group); group II (the HA group), humic acid (562 mg/kg) was given over 10 days by oral gavage; group III (the iron group), iron III hydroxide polymaltose (250 mg/kg) was given over 10 days by intraperitoneal route; and group IV (the HA plus iron group), received the iron (similar to group II) plus humic acid (similar to those in groups II and III) group. Blood and two tissue samples both from liver and heart were obtained for biochemical and histopathological evaluations. Iron deposition, the iron-induced hepatotoxicity, and cardiotoxicity were demonstrated by histopathological and biochemical manner. However, no significant differences were observed in the serum biochemical values and the histopathological results among the iron and the HA plus iron groups in the liver tissue but not in the heart tissue. The protective effects of humic acid against iron-induced cardiotoxicity were shown but not against hepatotoxicity in our study.en_US
dc.identifier.doi10.1007/s12011-015-0507-0
dc.identifier.endpage155en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1en_US
dc.identifier.pmid26380988en_US
dc.identifier.scopus2-s2.0-84941711680en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage145en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-015-0507-0
dc.identifier.urihttps://hdl.handle.net/11616/96976
dc.identifier.volume171en_US
dc.identifier.wosWOS:000374390100021en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIronen_US
dc.subjectHepatotoxicityen_US
dc.subjectHumic aciden_US
dc.subjectChelationen_US
dc.subjectCardiotoxicityen_US
dc.titleThe Acute Effect of Humic Acid on Iron Accumulation in Ratsen_US
dc.typeArticleen_US

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