Pyridoxine-dependent seizures: Magnetic resonance spectroscopy findings
Küçük Resim Yok
Tarih
2004
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
B C Decker Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Pyridoxine-dependent seizures are an extremely rare genetic disorder. Early diagnosis and treatment are important for the prevention of permanent. brain damage. Elevated levels of glutamate and decreased levels of gamma-aminobutyric acid (GABA) in the frontal and parietal cortices are among the characteristic features of this disorder. These metabolic abnormalities eventually lead to seizures and neuronal loss. In this case report, we present magnetic resonance spectroscopy findings of a 9-year-old girl with pyridoxine-dependent seizures with mental retardation. The N-acetylaspartate-to-creatine, ratio was found to be decreased in the frontal and parieto-occipital cortices, which could indicate neuronal loss. Magnetic resonance Spectroscopy could be a useful tool in the neuroiniaging evaluation for assessment of parenchymal changes despite a normal-appearing brain magnetic resonance image in patients with pyridoxine-dependent seizures.
Açıklama
Anahtar Kelimeler
Epilepsy, Brain, Mri
Kaynak
Journal of Child Neurology
WoS Q Değeri
Q2
Scopus Q Değeri
N/A
Cilt
19
Sayı
1
