Does single dose premedication of dexmedetomidine reduce pain during injection of propofol?

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dc.authorscopusid7801413617
dc.authorscopusid55898201200
dc.authorscopusid8932188900
dc.authorscopusid8861779800
dc.authorscopusid7004486274
dc.contributor.authorErdil F.A.
dc.contributor.authorGulhas N.
dc.contributor.authorBut A.K.
dc.contributor.authorBegec Z.
dc.contributor.authorErsoy M.O.
dc.date.accessioned2024-08-04T19:59:17Z
dc.date.available2024-08-04T19:59:17Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and objective: Pain on injection is still a major problem with propofol. In this study, we compared the efficacy of single-dose premedication of dexmedetomidine for pain on injection of propofol and its effect on the incidence and the severity of the pain after propofol injection. Methods: We conducted a prospective, randomized and double-blind study of 100 patients scheduled to undergo surgery. Patients were randomly assigned to one of two groups, either receiving dexmedetomidine (Group D) or saline (Group C) before the injection of propofol. Patients in Group D (n = 50) were given dexmedetomidine infusion 0.6 ?g/kg for 10 min. Patients in Group C (n = 50) were given saline infusion in an identical manner. Pain perception was assessed during injection of propofol in all patients. Results: The median pain score on injection of propofol was significantly lower in Group D than in Group C (median pain score 2 [1-3] vs 1 [0-2]; P < 0.006). The number of patients with pain in Group D decreased (48/50 [96%] in Group C vs 42/50 [84%] in Group D; P = 0.046). Conclusions: Intravenous administration of a single dose of dexmedetomidine as a premedication reduced the incidence and severity of pain on propofol injection without significant adverse haemodynamic effects. © 2007 W.S. Maney & Son Ltd.en_US
dc.identifier.doi10.1179/016911107X217437
dc.identifier.endpage25en_US
dc.identifier.issn0169-1112
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-34748895024en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://doi.org/10.1179/016911107X217437
dc.identifier.urihttps://hdl.handle.net/11616/90524
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofPain Clinicen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnalgesiaen_US
dc.subjectDexmedetomidineen_US
dc.subjectPropofolen_US
dc.titleDoes single dose premedication of dexmedetomidine reduce pain during injection of propofol?en_US
dc.typeArticleen_US

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