Factors Relating to Tumor Size and Survival in Patients with Hepatocellular Carcinoma: Significance of Platelet-Lymphocyte Ratio, Portal Vein Thrombosis, and Albumin

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dc.contributor.authorDonghia, Rossella
dc.contributor.authorCarr, Brian Irving
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2026-04-04T13:33:16Z
dc.date.available2026-04-04T13:33:16Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractIntroduction: Maximum tumor diameter (MTD) is one of the key aggressiveness features of hepatocellular carcinoma (HCC). However, the clinical associations and causes of large size HCC are not well understood. The aim was to compare small and large MTD (<=/>6 cm) HCCs with respect to clinical associations. Methods: MTD <=/> 6 cm HCCs were compared by clinical characteristics and analyzed through logistical regression models, as well as Cox proportional hazard models for death, on clinical parameters. Results: Patients with larger HCCs had more portal vein thrombosis (PVT) and tumor multifocality, higher AST, ALKP and GGT levels and lower albumin levels. A logistic regression model of MTD (<=/>6 cm) showed the highest risk for PVT and platelet-lymphocyte ratio (PLR) >150, while albumin and female gender were protective. The combination of male gender, PLR >150, plus PVT had an odds ratio of 12.124. In Cox proportional hazard models, the highest hazard ratio for death was for PVT, and only albumin was significantly protective. PVT plus low albumin had a hazard ratio of 4.254. Conclusion: PVT, albumin, PLR, and gender were significant for <=/>6 cm MTD. PVT and albumin were significant for survival.
dc.description.sponsorshipNIH grant [CA 82723]; Italian Ministry of Health Ricerca Corrente
dc.description.sponsorshipThis work was supported in part by NIH grant CA 82723(B.I.C.), and the Italian Ministry of Health Ricerca Corrente 2025.
dc.identifier.doi10.1159/000545636
dc.identifier.endpage155
dc.identifier.issn0030-2414
dc.identifier.issn1423-0232
dc.identifier.issue2
dc.identifier.orcid0000-0002-6111-5077
dc.identifier.orcid0000-0002-9140-673X
dc.identifier.pmid40199256
dc.identifier.scopus2-s2.0-105008178980
dc.identifier.scopusqualityQ2
dc.identifier.startpage145
dc.identifier.urihttps://doi.org/10.1159/000545636
dc.identifier.urihttps://hdl.handle.net/11616/109049
dc.identifier.volume104
dc.identifier.wosWOS:001504634500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofOncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectHepatocellular carcinoma
dc.subjectMaximum tumor diameter
dc.subjectPortal vein thrombosis
dc.subjectAlbumin
dc.subjectGender
dc.subjectPlatelet-lymphocyte ratio
dc.subjectSurvival
dc.titleFactors Relating to Tumor Size and Survival in Patients with Hepatocellular Carcinoma: Significance of Platelet-Lymphocyte Ratio, Portal Vein Thrombosis, and Albumin
dc.typeArticle

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