Protective role of melatonin given either before ischemia or prior to reperfusion on intestinal ischemia-reperfusion damage

Basit Öğe Kaydı
dc.authoridGeckil, Hikmet/0000-0003-0070-0691
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authorwosidFiskin, Kayahan/C-2434-2016
dc.authorwosidGeckil, Hikmet/F-7647-2012
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.contributor.authorAtes, B
dc.contributor.authorYilmaz, I
dc.contributor.authorGeckil, H
dc.contributor.authorIraz, M
dc.contributor.authorBirincioglu, M
dc.contributor.authorFiskin, K
dc.date.accessioned2024-08-04T20:30:52Z
dc.date.available2024-08-04T20:30:52Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTissue injury resulting from ischemia-reperfusion is of fundamental importance. Experimental evidence suggests that the generation of reactive oxygen species is significantly responsible for this type of injury. In the present study, besides investigating the protective role of melatonin on tissue damage caused by intestinal ischemia-reperfusion, the protective activity of this compound was also analyzed in both pre- and post ischemia melatonin-treated rats. The activities of the main antioxidative enzymes, catalase, superoxide dismutase and glutathione peroxidase in the intestine showed significant (P < 0.05) increases in melatonin-treated animals that were subjected to ischemia/reperfusion compared with those subjected only to ischemia/reperfusion. Also, results clearly indicate that the level of malondialdeyhde, an index of lipid peroxidation, decreased significantly (P < 0.05) when rats subjected to intestinal/reperfusion were given melatonin either before ischemia or before reperfusion.en_US
dc.identifier.doi10.1111/j.1600-079X.2004.00148.x
dc.identifier.endpage152en_US
dc.identifier.issn0742-3098
dc.identifier.issn1600-079X
dc.identifier.issue3en_US
dc.identifier.pmid15357658en_US
dc.identifier.scopus2-s2.0-4644221875en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage149en_US
dc.identifier.urihttps://doi.org/10.1111/j.1600-079X.2004.00148.x
dc.identifier.urihttps://hdl.handle.net/11616/94580
dc.identifier.volume37en_US
dc.identifier.wosWOS:000223709000002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Pineal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidative enzymesen_US
dc.subjectfree radicalsen_US
dc.subjectintestinal ischemia-reperfusionen_US
dc.subjectmalondialdehydeen_US
dc.subjectmelatoninen_US
dc.subjectoxidative stressen_US
dc.titleProtective role of melatonin given either before ischemia or prior to reperfusion on intestinal ischemia-reperfusion damageen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu