Curcumin prevents toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral immunity in rats

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dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.contributor.authorCiftci, Osman
dc.date.accessioned2024-08-04T20:32:44Z
dc.date.available2024-08-04T20:32:44Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstract2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure results in adverse effects on the immune system of experimental animals. In this study, the negative effects of TCDD on the humoral immunity of rats and the preventive effects of curcumin were examined. For this purpose, TCDD and curcumin were given to the experimental and control groups. Then, the serum samples taken from all rats at 15, 30, 45 and 60th days were analysed for the determination of immunoglobulins (Igs) and complements (Cs) level by enzyme-linked immunosorbent assay method. The results indicated that TCDD caused significant decrease (P < 0.05) in serum IgG and IgM levels. However, it caused significant (P < 0.05) increase in the levels of C3 in rats. On the contrary, curcumin decreases C3 activity, but increases IgG and IgM levels in rats. In conclusion, TCDD significantly suppressed the humoral immunity in rats. However, curcumin eliminated the toxic effects of TCDD when it was given together with TCDD.en_US
dc.description.sponsorshipTUBITAK (Scientific and Technical Research Council of the Turkish Republic) [106O815]en_US
dc.description.sponsorshipIt is a great pleasure to thank TUBITAK (Scientific and Technical Research Council of the Turkish Republic) for their financial support during our project under Grant 106O815.en_US
dc.identifier.doi10.1080/09540105.2010.517308
dc.identifier.endpage38en_US
dc.identifier.issn0954-0105
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-79952410843en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage31en_US
dc.identifier.urihttps://doi.org/10.1080/09540105.2010.517308
dc.identifier.urihttps://hdl.handle.net/11616/95273
dc.identifier.volume22en_US
dc.identifier.wosWOS:000288003100003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofFood and Agricultural Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTCDDen_US
dc.subjectimmunoglobulinen_US
dc.subjectcomplementen_US
dc.subjectcurcuminen_US
dc.subjecthumoral immunityen_US
dc.titleCurcumin prevents toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral immunity in ratsen_US
dc.typeArticleen_US

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