Protective effect of royal jelly on fluoride-induced nephrotoxicity in rats via the some protein biomarkers signalling pathways: a new approach for kidney damage

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dc.authoridGök, Özlem/0000-0001-8521-6369
dc.authoridParlak, Gozde/0000-0002-8982-887X
dc.authoridBeyaz, Seda/0000-0003-0436-8112
dc.authoridCan, Muhammed Ismail/0000-0002-0118-2278
dc.authoridBaspinar, Serpil/0000-0001-9496-2451
dc.authoridAslan, Abdullah/0000-0002-6243-4221
dc.authorwosidCan, Muhammed İsmail/ABG-8646-2020
dc.authorwosidGök, Özlem/AFV-8223-2022
dc.authorwosidParlak, Gozde/ISA-6808-2023
dc.authorwosidcan, mi/KDN-4165-2024
dc.authorwosidBaspinar, Serpil/V-8526-2018
dc.authorwosidAslan, Abdullah/C-9523-2016
dc.contributor.authorAslan, Abdullah
dc.contributor.authorBeyaz, Seda
dc.contributor.authorGok, Ozlem
dc.contributor.authorCan, Muhammed Ismail
dc.contributor.authorParlak, Gozde
dc.contributor.authorGundogdu, Ramazan
dc.contributor.authorOzercan, Ibrahim Hanifi
dc.date.accessioned2024-08-04T20:52:06Z
dc.date.available2024-08-04T20:52:06Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction Protective effect of royal jelly (RJ) on fluoride-induced nephrotoxicity was investigated in this study. Methods 42 healthy male Wistar rats (n = 42, 8 weeks of age) were divided equally into 6 groups with 7 rats in each; (1) Group-1: Controls fed with standard diet; (2) Group-2: RJ [100 mg/kg] bw (body weight), by oral gavage; (3) Group-3: Fluoride [50 mg/kg] bw, in drinking water; (4) Group-4: Fluoride [100 mg/kg] bw, in drinking water; (5) Group-5: RJ [100 mg/kg] bw, by oral gavage + Fluoride [50 mg/kg] bw, in drinking water; (6) Group-6: RJ [100 mg/kg] bw, by oral gavage + Fluoride [100 mg/kg] bw, in drinking water. After 8 weeks, all rats were decapitated and their kidney tissues were removed for further analysis. The protein expression levels of caspase-3, caspase-6, caspase-9, Bcl-2, Bax, VEGF, GSK-3, BDNF, COX-2 and TNF-alpha proteins in kidney tissue were analysed by western blotting technique Results RJ increased Bcl-2, COX-2, GSK-3, TNF-alpha and VEGF protein levels and a decreased caspase-3, caspase -6, caspase-9, Bax and BDNF protein levels in fluoride-treated rats. Conclusion RJ application may have a promising therapeutical potential in the treatment of many diseases in the future by reducing kidney damage.en_US
dc.description.sponsorshipFirat University Research Projects Unit (FUBAP) [19.16]en_US
dc.description.sponsorshipPresent study was supported by Firat University Research Projects Unit (FUBAP) [Grant No. FF. 19.16].en_US
dc.identifier.doi10.1080/1354750X.2022.2093977
dc.identifier.endpage647en_US
dc.identifier.issn1354-750X
dc.identifier.issn1366-5804
dc.identifier.issue7en_US
dc.identifier.pmid35735023en_US
dc.identifier.scopus2-s2.0-85133282302en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage637en_US
dc.identifier.urihttps://doi.org/10.1080/1354750X.2022.2093977
dc.identifier.urihttps://hdl.handle.net/11616/100761
dc.identifier.volume27en_US
dc.identifier.wosWOS:000819538100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiomarkersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectBDNFen_US
dc.subjectcaspase-9en_US
dc.subjectCOX-2en_US
dc.subjectGSK-3en_US
dc.subjectroyal jellyen_US
dc.titleProtective effect of royal jelly on fluoride-induced nephrotoxicity in rats via the some protein biomarkers signalling pathways: a new approach for kidney damageen_US
dc.typeArticleen_US

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