Serum homocysteine level is increased and correlated with endothelin-1 and nitric oxide in Behcet's disease

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720;
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidEvereklioğlu, Cem/A-5370-2018
dc.contributor.authorEr, H
dc.contributor.authorEvereklioglu, C
dc.contributor.authorCumurcu, T
dc.contributor.authorTürköz, Y
dc.contributor.authorÖzerol, E
dc.contributor.authorSahin, K
dc.contributor.authorDoganay, S
dc.date.accessioned2024-08-04T20:13:08Z
dc.date.available2024-08-04T20:13:08Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/aims: Beligei's disease (BD) is a systemic inflammatory vasculitis of young adults with unknown aetiology, characterised by endothelial dysfunction and occlusion in both deep venous and retinal circulation. Ocular involvement occurs in 70% of cases and is characterised by periphlebitis, periarteritis, vascular occlusion, and thrombosis leading to blindness despite vigorous treatment. Endothelin-1 (ET-1) is a vasoconstricting peptide while nitric oxide (NO) is a relaxing molecule and both are released by endothelium for blood flow regulation. Homocysteinaemia is a newly defined term connected to the increased risk of atherothrombotic and atherosclerotic systemic and retinal vascular occlusive diseases, and its role in the course of BID has not been previously described. The authors aimed to detect serum total homocysteine (tHcy), ET-1, and NO in BID and to assess if tHcy, ET-1, and NO are associated with ocular BD or disease activity. Methods: 43 consecutive patients with ocular (n = 27) or non-ocular (n = 16) BD (36.95 (SD 9.80) years, 22 male, 21 female) satisfying international criteria, and 25 age and sex matched healthy control subjects (37.88 (8.73) years, 13 male, 12 female) without a history of systemic or retinal venous thrombosis were included in this study. Patients were examined by two ophthalmologists with an interest in BID. Serum tHcy, ET-1, and NO concentrations were measured in both groups. Hype rhomocysteinaemia was defined as a tHcy level above the 95th percentile in the control group. Patients were divided into active and inactive period by acute phase reactants including (X, antitrypsin, alpha(2), macroglobulin, erythrocyte sedimentation rate, and neutrophil count. Results: The overall mean serum tHcy, ET-1, and NO levels were significantly higher in patients with BD than in control subjects (tHcy = 15,83 (4.44) v7.96 (2.66) ng/ml, p <0.001; ET-1 = 17.47 (4.33) v 5.74 (2.34) mumol/ml, p <0.001; NO = 37.60 (10.31) v 27.08 (7.76) mumol/l, p <0.00 1). Serum I tHcy, ET-1, and NO levels were significantly higher in active patients than in inactive patients and control subjects. In addition, among patients with ocular BID, the mean tHcy levels were significantly increased and correlated with ET-1 and NO levels when compared with non-ocular disease and control subjects. All acute phase reactant levels were significantly higher in active period than in inactive stage and controls. Conclusions: Elevated tHcy may be responsible for the endothelial damage in BD and may be an additional risk Factor for the development of retinal vascular occlusive disease, contributing to the poor visual outcome in these patients. Assessment of tHcy may be important in the investigation and management of patients with BD, especially with ocular disease.en_US
dc.identifier.doi10.1136/bjo.86.6.653
dc.identifier.endpage657en_US
dc.identifier.issn0007-1161
dc.identifier.issn1468-2079
dc.identifier.issue6en_US
dc.identifier.pmid12034688en_US
dc.identifier.scopus2-s2.0-0036280103en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage653en_US
dc.identifier.urihttps://doi.org/10.1136/bjo.86.6.653
dc.identifier.urihttps://hdl.handle.net/11616/93398
dc.identifier.volume86en_US
dc.identifier.wosWOS:000176165700015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmj Publishing Groupen_US
dc.relation.ispartofBritish Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRetinal Vein Occlusionen_US
dc.subjectRisk Factoren_US
dc.subjectInvolvementen_US
dc.subjectHyperhomocysteinemiaen_US
dc.subjectDysfunctionen_US
dc.subjectExpressionen_US
dc.subjectArterialen_US
dc.titleSerum homocysteine level is increased and correlated with endothelin-1 and nitric oxide in Behcet's diseaseen_US
dc.typeArticleen_US

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