The Effects of Omega-3 Supplementation Combined with Strength Training on Neuro-Biomarkers, Inflammatory and Antioxidant Responses, and the Lipid Profile in Physically Healthy Adults

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dc.contributor.authorOkut, Sedat
dc.contributor.authorOzan, Murat
dc.contributor.authorBuzdagli, Yusuf
dc.contributor.authorUcar, Halil
dc.contributor.authorInac, Muhammet Rasit
dc.contributor.authorHan, Muhammet Talha
dc.contributor.authorBayram, Esra
dc.date.accessioned2026-04-04T13:30:59Z
dc.date.available2026-04-04T13:30:59Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractObjectives: This study aimed to comprehensively investigate the physiological effects of omega-3 fatty acid supplementation combined with resistance training on the lipid profile, inflammatory and antioxidant responses, neuro-biomarkers, and physical performance parameters in physically healthy young adults. Methods: Thirty physically active male participants were randomly assigned to an experimental group (omega-3 + resistance training) or a control group (resistance training only). Over eight weeks, both groups performed a standardized resistance training program three times per week. The experimental group additionally received 3150 mg/day of omega-3 fatty acids (EPA and DHA). Pre- and post-intervention assessments included blood biomarkers (LDL, HDL, triglycerides, IL-6, TNF-alpha, CRP, GSH, MDA, BDNF, serotonin, and dopamine) and physical performance tests (1RM, CMJ, RSI, 10 m sprint, and Illinois agility). Results: The experimental group showed significant improvements in the lipid profile, with decreases in LDL and triglyceride levels and an increase in HDL levels. Levels of the inflammatory cytokines IL-6 and TNF-alpha were significantly reduced, while GSH levels increased and MDA levels decreased, indicating an enhanced antioxidant status. The neuro-biomarker analysis revealed increased levels of BDNF, dopamine, and serotonin. Physical performance tests demonstrated greater improvements in muscular strength, power, speed, agility, and reaction-based performance in the omega-3 group compared to controls. Conclusions: These findings suggest that omega-3 supplementation, when combined with resistance training, has a multi-systemic enhancing effect on both physiological markers and physical performance. This combination may represent a promising strategy for optimizing athletic adaptations and recovery in physically active populations. Future studies should further explore these effects across different populations and training modalities.
dc.identifier.doi10.3390/nu17132088
dc.identifier.issn2072-6643
dc.identifier.issue13
dc.identifier.orcid0000-0002-3584-5252
dc.identifier.orcid0000-0003-1809-5194
dc.identifier.orcid0000-0002-4231-1267
dc.identifier.orcid0009-0008-5547-3805
dc.identifier.pmid40647193
dc.identifier.scopus2-s2.0-105010581906
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/nu17132088
dc.identifier.urihttps://hdl.handle.net/11616/108496
dc.identifier.volume17
dc.identifier.wosWOS:001526234100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofNutrients
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectOmega-3 fatty acids
dc.subjectresistance training
dc.subjectneuro-biomarkers
dc.subjectinflammatory response
dc.subjectantioxidant capacity
dc.titleThe Effects of Omega-3 Supplementation Combined with Strength Training on Neuro-Biomarkers, Inflammatory and Antioxidant Responses, and the Lipid Profile in Physically Healthy Adults
dc.typeArticle

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