Evaluation of second trimester plasma lipoxin A4, VEGFR-1, IL-6, and TNF-a levels in pregnant women with gestational diabetes mellitus

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dc.authoridİnceoğlu, Feyza/0000-0003-1453-0937
dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authorwosidİnceoğlu, Feyza/GVK-2847-2022
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.contributor.authorKiran, Tugba Raika
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorOtlu, Onder
dc.contributor.authorInceoglu, Feyza
dc.contributor.authorKarabulut, Ercan
dc.contributor.authorErenler, Ayse Sebnem
dc.date.accessioned2024-08-04T20:54:46Z
dc.date.available2024-08-04T20:54:46Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, our objective was to explore the association between gestational diabetes mellitus (GDM) and second trimester maternal plasma levels of lipoxin A4 (LXA4), along with proinflammatory markers such as interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-a), and the anti-angiogenic factor vascular endothelial growth factor receptor 1 (VEGFR-1) in pregnant women. The study included a cohort of 30 pregnant women with GDM and a control group of 30 normoglycaemic pregnant women matched for age, body mass index, and gestational age. Plasma samples were collected and analysed by enzyme-linked immunosorbent assay to assess specific biomarkers. The GDM group had significantly lower levels of LXA4 and higher levels of TNF-a and VEGFR-1 compared to the control group (p = 0.038, p = 0.025, and p = 0.002, respectively). A statistically significant decrease in the LXA4/TNF-a ratio was observed in the GDM group (p = 0.004). The results suggest that each unit decrease in the LXA4/TNF-a ratio is associated with a 1.280-fold increase in the risk of GDM. These findings suggest a potential diagnostic role for the LXA4/TNFa ratio as a marker for women with GDM. This work provides new insights into the pathogenesis of GDM and highlights the important interplay between inflammation and metabolic dysregulation.en_US
dc.description.sponsorshipScientific Research Supportment Commitee of Malatya Turgut Ozal University, Malatya, Turkey; [2021/9]en_US
dc.description.sponsorshipThis research was supported by the Scientific Research Supportment Commitee of Malatya Turgut Ozal University, Malatya, Turkey (Project no: 2021/9)en_US
dc.identifier.doi10.1515/chem-2023-0121
dc.identifier.issn2391-5420
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85173513531en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1515/chem-2023-0121
dc.identifier.urihttps://hdl.handle.net/11616/101609
dc.identifier.volume21en_US
dc.identifier.wosWOS:001069806400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDe Gruyter Poland Sp Z O Oen_US
dc.relation.ispartofOpen Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectgestational diabetes mellitusen_US
dc.subjectlipoxin A4en_US
dc.subjectpro-inflammatory cytokinesen_US
dc.subjecttumour necrosis factor-alphaen_US
dc.subjectvascular endothelial growth factor receptor-1en_US
dc.titleEvaluation of second trimester plasma lipoxin A4, VEGFR-1, IL-6, and TNF-a levels in pregnant women with gestational diabetes mellitusen_US
dc.typeArticleen_US

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