Serum bilirubin and uric acid antioxidant levels in rosacea patients

Basit Öğe Kaydı
dc.authoridTürkmen, Dursun/0000-0001-9076-4669
dc.authorwosidTürkmen, Dursun/ABG-3801-2020
dc.contributor.authorTurkmen, Dursun
dc.date.accessioned2024-08-04T20:47:13Z
dc.date.available2024-08-04T20:47:13Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Rosacea is a common chronic inflammatory skin disease that the pathogenesis is not fully understood. Although the significant role of oxidative stress in rosacea pathophysiology has been shown in recent studies, there is no study addressing the potential roles of bilirubin and uric acid (UA) in rosacea. Aim The purpose of this study was to assign serum bilirubin and UA antioxidant levels in rosacea patients. Methods Eighty-seven rosacea patients and 81 healthy controls (HCs) similar age and gender were included in the study. From all study participants, blood samples were taken and the values of total bilirubin (Tbil), direct bilirubin (Dbil), indirect bilirubin (Ibil), and UA were analyzed in the laboratory of biochemistry. Results The type of rosacea was erythematotelangiectatic in 51.7% of the patients, papulopustular in 43.7%, and phymatous in 4.6%. In rosacea group serum, Tbil, Dbil, Ibil, and UA values were found to be significantly lower than in the HCs. Male rosacea patients were found to have lower Tbil, Dbil, Ibil, and UA levels when compared with the males in the HCs. There was also the same significant difference in female patients. Conclusion Main finding of our study was that when compared with the control group, serum bilirubin and UA levels were significantly lower in rosacea patients. These levels sustain the hypothesis that antioxidant status and oxidative stress are important in the pathogenesis of rosacea.en_US
dc.identifier.doi10.1111/jocd.13395
dc.identifier.endpage2720en_US
dc.identifier.issn1473-2130
dc.identifier.issn1473-2165
dc.identifier.issue10en_US
dc.identifier.pmid32233016en_US
dc.identifier.scopus2-s2.0-85082571881en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2717en_US
dc.identifier.urihttps://doi.org/10.1111/jocd.13395
dc.identifier.urihttps://hdl.handle.net/11616/99237
dc.identifier.volume19en_US
dc.identifier.wosWOS:000522531300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Cosmetic Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectoxidative stressen_US
dc.subjectRosaceaen_US
dc.subjectserum bilirubinen_US
dc.subjecturic aciden_US
dc.titleSerum bilirubin and uric acid antioxidant levels in rosacea patientsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu