Impact of COVID-19 pandemic on clinicopathological features of transplant recipients with hepatocellular carcinoma: A case-control study

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dc.authoridince, volkan/0000-0002-0714-490X
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authorwosidince, volkan/M-7325-2017
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.contributor.authorAkbulut, Sami
dc.contributor.authorSahin, Tevfik Tolga
dc.contributor.authorInce, Volkan
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:51:59Z
dc.date.available2024-08-04T20:51:59Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND The coronavirus disease 2019 (COVID-19) pandemic had a significant impact on the management of all diseases. Various diseases such as cancer have a higher risk of COVID-19-related death. Despite this fact, any delay or alteration in treatment of cancer may have fatal consequences. Hepatocellular carcinoma (HCC) is an aggressive liver cancer that requires multimodality treatment to improve survival. AIM To evaluate the impact of COVID-19 on the management of patients with HCC by determining changes in demographic, clinical and histopathological variables. METHODS Demographic, clinical and pathological variables of patients with HCC who had undergone liver transplantation between March 2020 and June 2021 (Pandemic group, n = 48) were retrospectively compared with that of the patients with HCC transplanted between November 2018 and March 2020 (Pre-pandemic group, n = 61). RESULTS The median age of the patients in the study was 56 (interquartile range = 15). Ninety-seven patients (89%) were male and 12 were female (11%). The most common etiology of liver disease was hepatitis B virus (n = 52, 47.7%). According to our results, there was a 21.3% drop in the number of patients transplanted for HCC. There was no difference in the demographic, clinical and pathological characteristics of the patients except blood alkaline phosphatase levels (P = 0.029), lymphovascular invasion (P = 0.019) and type of the liver graft that was transplanted (P = 0.017). CONCLUSION It is important to develop a surveillance strategy for liver transplant centers. The liver transplantation for HCC is justified and safe provided that strict surveillance protocols are applied.en_US
dc.identifier.doi10.12998/wjcc.v10.i15.4785
dc.identifier.endpage4798en_US
dc.identifier.issn2307-8960
dc.identifier.issue15en_US
dc.identifier.pmid35801031en_US
dc.identifier.scopus2-s2.0-85131065773en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage4785en_US
dc.identifier.urihttps://doi.org/10.12998/wjcc.v10.i15.4785
dc.identifier.urihttps://hdl.handle.net/11616/100680
dc.identifier.volume10en_US
dc.identifier.wosWOS:000812133700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal of Clinical Casesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19 pandemicen_US
dc.subjectLiver transplantationen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectBiological behavioren_US
dc.titleImpact of COVID-19 pandemic on clinicopathological features of transplant recipients with hepatocellular carcinoma: A case-control studyen_US
dc.typeArticleen_US

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