HLA-A, -B,-DRB1 Allele and Haplotype Frequencies and Comparison With Blood Group Antigens in Dialysis Patients in the East Anatolia Region of Turkey

Basit Öğe Kaydı
dc.authoridKAYHAN, BASAK/0000-0003-3508-2563
dc.authoridtaskapan, hulya/0000-0001-8736-4779
dc.authoridSahin, Idris/0000-0002-8683-3737
dc.authoridKURTOĞLU, Elçin Latife/0000-0002-8375-8399;
dc.authorwosidKAYHAN, BASAK/ABH-9314-2020
dc.authorwosidtaskapan, hulya/ABI-7737-2020
dc.authorwosidSahin, Idris/AAS-4390-2020
dc.authorwosidKURTOĞLU, Elçin Latife/AAQ-6842-2020
dc.authorwosidPiskin, Turgut/HKV-8614-2023
dc.authorwosidASLAN, Elçin Latife/A-3923-2017
dc.contributor.authorKayhan, B.
dc.contributor.authorKurtoglu, E. L.
dc.contributor.authorTaskapan, H.
dc.contributor.authorPiskin, T.
dc.contributor.authorSahin, I.
dc.contributor.authorOtlu, G.
dc.contributor.authorUnal, B.
dc.date.accessioned2024-08-04T20:37:46Z
dc.date.available2024-08-04T20:37:46Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim. The first aim of that study was to investigate HLA class I and class II allele and haplotype frequencies in renal dialysis patients who live in East Anatolia in Turkey. Our second aim was to investigate whether there was a relationship between ABO and D blood group antigens and HLA alleles and haplotypes for the study group. Materials and methods. HLA class I and II polymorphisms in 408 renal dialysis patients were studied using sequence-specific primers (SSP) and sequence-specific oligonucleotides (SSO). Blood group antigens were detected by agglutination methods on microplates. Results. A total of 16 HLA-A, 34 HLA-B, and 15 HLA-DRB1 alleles were identified. The most frequent HLA-A alleles were HLA-A*02, HLA-A*24, and HLA-A*11. The most frequent HLA-B alleles were HLA-B*35, HLA-B*51, and HLA-B*44. In case of HLA-DRB1; HLA-DRB1*11, HLA-DRB1*04, and HLA-DRB1*13 were first 3 alleles with higher frequency, in order. In the combination of those 3 alleles, the most frequent HLA-A-B-DRB1 haplotypes were HLA-A*02-B*51-DRB1*11, HLA-A*11-B*35-DRB1*11, A*24-B*35-DRB1*11. The frequency of ABO, D blood group antigens were observed as 0.168 for A Rh(+), 0.019 for A Rh(-), 0.057 for B Rh(+), 0.013 for B Rh(-), 0.123 for O Rh(+), 0.014 for O Rh(-), 0.018 for AB Rh(+), and 0.001 for AB Rh(-). While A Rh(+) samples with HLA-A*02 and HLA-DRB1*11 had the highest frequencies (0.067 and 0.088, respectively), O Rh(+) samples with HLA-B*51 had the highest frequency (0.06). Conclusion. According to haplotype frequencies HLA-A*02-B*51-DRB1*11 is also found at higher frequencies in Bulgarian and Armenian populations. In case of HLA-associated diseases, the east Anatolian population could be susceptible to myastenia gravis, Behcet's disease, and systemic sclerosis due to the high frequencies of HLA-A*24, HLA-B*51, and HLA-DRB1*11 respectively. We did not observe a correlation between blood group antigens and HLA alleles or haplotypes in renal dialysis patients.en_US
dc.identifier.doi10.1016/j.transproceed.2013.03.034
dc.identifier.endpage2128en_US
dc.identifier.issn0041-1345
dc.identifier.issue6en_US
dc.identifier.pmid23953521en_US
dc.identifier.scopus2-s2.0-84882286832en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2123en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2013.03.034
dc.identifier.urihttps://hdl.handle.net/11616/96176
dc.identifier.volume45en_US
dc.identifier.wosWOS:000323852000009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClass-Ien_US
dc.subjectPopulationen_US
dc.subjectPolymorphismen_US
dc.subjectDiseaseen_US
dc.subjectGreeksen_US
dc.titleHLA-A, -B,-DRB1 Allele and Haplotype Frequencies and Comparison With Blood Group Antigens in Dialysis Patients in the East Anatolia Region of Turkeyen_US
dc.typeArticleen_US

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