Urinary excretion of deoxypyridinoline in 24-hour and first-void samples in healthy Turkish children

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dc.authoridKutlu, Nurettin Onur/0000-0002-3306-6570
dc.authorwosidKutlu, Nurettin Onur/AAW-6196-2021
dc.contributor.authorSoylu, H
dc.contributor.authorAras, S
dc.contributor.authorKutlu, NO
dc.contributor.authorEgri, M
dc.contributor.authorSahin, K
dc.date.accessioned2024-08-04T20:12:08Z
dc.date.available2024-08-04T20:12:08Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Collagen cross-links are formed during the maturation process of bone matrix. They have been considered as valuable markers in some metabolic, endocrinologic, and neoplastic bone disorders. As an advantage, it can be measured in urine as well as in serum samples. However, the excretion characteristics remains controversial. Design and methods: We investigated urinary free deoxypyridinoline (f-Dpd) excretion in first-void urine samples and in 24-hour collections in healthy Turkish children. We also evaluated the possible correlations and gender-related differences in Dpd excretion between these sampling methods. Both urine samples of 62 subjects (aged from 31 to 120 months) were analyzed by Immulite chemiluminescent technique. Results: There were no remarkable differences in f-Dpd excretion between first-void and 24-hour urine samples, although f-Dpd values of the first-void samples were slightly higher (Dpd: creatinine, mean +/- SD, 20.5 +/-; 5.8 nmol/mmol vs. 19.6 +/- 5.6 nmol/mmol, respectively, p > 0.05), A strong linear correlation was found between 24-hour and first-void urine f-Dpd excretions (r = 0.77, p < 0.05). In addition, f-Dpd showed no gender-related differences between boys and girls in either 24-hour or first-void urine samples (p > 0.05). Conclusions: Because of difficulties in long-time urine collection in infants and young children, f-Dpd assessment in first-void single urine samples is an easy, safe, and non-invasive method. Copyright (C) 2000 The Canadian Society of Clinical Chemists.en_US
dc.identifier.doi10.1016/S0009-9120(00)00072-2
dc.identifier.endpage272en_US
dc.identifier.issn0009-9120
dc.identifier.issue4en_US
dc.identifier.pmid10936584en_US
dc.identifier.scopus2-s2.0-0033843201en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage269en_US
dc.identifier.urihttps://doi.org/10.1016/S0009-9120(00)00072-2
dc.identifier.urihttps://hdl.handle.net/11616/93229
dc.identifier.volume33en_US
dc.identifier.wosWOS:000089044300004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofClinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdeoxypyridinolineen_US
dc.subjectchildhooden_US
dc.subjectfirst-void single urineen_US
dc.titleUrinary excretion of deoxypyridinoline in 24-hour and first-void samples in healthy Turkish childrenen_US
dc.typeArticleen_US

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