Knee Arthralgia and Cartilage Thinning in Psoriasis: Clues to Early Psoriatic Arthritis?

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dc.contributor.authorAkturk, Semra
dc.contributor.authorBuyukavci, Raikan
dc.contributor.authorZontul, Sezgin
dc.contributor.authorKanat, Zekiye
dc.contributor.authorAltunisik, Nihal
dc.contributor.authorAltun, Belda
dc.contributor.authorSimsek, Emrah
dc.date.accessioned2026-04-04T13:33:17Z
dc.date.available2026-04-04T13:33:17Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground: To compare femoral cartilage thickness between patients with psoriasis (PsO) and psoriatic arthritis (PsA), and to investigate whether knee joint pain in PsO patients could be an early risk factor for PsA. Methods: Fifty-nine patients (28 PsO and 31 PsA) were included in this cross-sectional study. Demographic data were collected, and clinical assessments were performed using the Psoriasis Area and Severity Index (PASI) and the Disease Activity Score 28 (DAS28). PsO patients were evaluated for knee arthralgia symptoms within the past month. Femoral cartilage thickness was measured bilaterally at the medial femoral condyle, lateral femoral condyle, and intercondylar area using ultrasonography. Results: Femoral cartilage thickness was significantly lower in PsA patients compared to those with PsO (p < 0.05). Among patients with PsO, those reporting arthralgia (n = 14) had significantly reduced lateral femoral condyle cartilage thickness in both knees compared to those without arthralgia (p < 0.05). Spearman correlation analysis revealed a negative correlation between age and lateral cartilage thickness (e.g., right LFC: rho = -0.338, p = 0.009, 95% CI -0.55 to -0.09). PASI scores showed a consistent positive correlation with femoral cartilage thickness across regions; for example, the correlation with the left LFC was significant (rho = 0.504, p < 0.01, 95% CI 0.29-0.67). These associations indicate that both demographic and disease-related factors may influence cartilage status in PsO and PsA, although the confidence intervals indicate some degree of uncertainty and call for validation in larger cohorts. Conclusions: Femoral cartilage thinning is evident in PsA patients and may begin even in the subclinical phase. In PsO patients, the presence of arthralgia, especially in the lateral femoral condyle, may reflect early structural changes and could serve as a predictor for PsA development. Ultrasonographic assessment offers a noninvasive, accessible method for early detection and follow-up.
dc.description.sponsorshipScientific Research Projects Unit of Malatya Idot;nn University
dc.description.sponsorshipGenerative AI Statement. The authors declare that no Generative AI was used in the creation of this manuscript.
dc.identifier.doi10.1155/ijcp/6096621
dc.identifier.issn1368-5031
dc.identifier.issn1742-1241
dc.identifier.issue1
dc.identifier.orcid0000-0002-2234-7158
dc.identifier.orcid0000-0001-6844-1097
dc.identifier.orcid0000-0001-9960-6851
dc.identifier.orcid0000-0001-5730-2286
dc.identifier.orcid0000-0001-9076-4669
dc.identifier.scopus2-s2.0-105018601091
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1155/ijcp/6096621
dc.identifier.urihttps://hdl.handle.net/11616/109056
dc.identifier.volume2025
dc.identifier.wosWOS:001589614300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Journal of Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectarthralgia
dc.subjectfemoral cartilage
dc.subjectpsoriasis
dc.subjectpsoriatic arthritis
dc.subjectultrasonography
dc.titleKnee Arthralgia and Cartilage Thinning in Psoriasis: Clues to Early Psoriatic Arthritis?
dc.typeArticle

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