CO-releasing properties and anticancer activities of manganese complexes with imidazole/benzimidazole ligands

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dc.authoridÜstün, Elvan/0000-0002-0587-7261
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridDüşünceli, Serpil Demir/0000-0001-8765-4039
dc.authoridTUTAR, Yusuf/0000-0003-2613-9644
dc.authorwosidTutar, Yusuf/JUV-7385-2023
dc.authorwosidÜstün, Elvan/HJB-1157-2022
dc.authorwosidDemir, Serpil/AAI-1740-2019
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.authorwosidÖzgür, Aykut/AAE-4823-2022
dc.authorwosidDüşünceli, Serpil Demir/AAA-7160-2021
dc.contributor.authorUstun, Elvan
dc.contributor.authorOzgur, Aykut
dc.contributor.authorCoskun, Kubra A.
dc.contributor.authorDemir, Serpil
dc.contributor.authorOzdemir, Ismail
dc.contributor.authorTutar, Yusuf
dc.date.accessioned2024-08-04T20:42:41Z
dc.date.available2024-08-04T20:42:41Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCarbon monoxide (CO) is an important signaling molecule which plays significant roles in the pathogenesis of cancer. CO is produced by enzymatic degradation of heme in mammals. Heme oxygenase 1 (HO-1) catalyzes the breakdown of heme into CO, ferrous iron, and biliverdin. CO induces HO-1 and inhibits cell proliferation. Cancer cells exposed to several stress factors (hypoxia, reactive oxygen species, cis-platin, and oxidative stress), and HO-1 displays cytoprotective role against oxidative stress and inhibits apoptosis, metastases, angiogenesis, and cell proliferation processes. Therefore, metal containing CO-releasing molecules (CORMs) have been designed as an effective cancer treatment strategy. CORMs are responsible for releasing controlled amounts of CO to cells and tissues. Thus, we synthesized [Mn(CO)(3)(bpy)L]X manganese containing CORMs [bpy=2,2-bipyridine, X=hexafluorophosphate (PF6), trifluoromethanesulfonate (OTf), L=imidazole, methylimidazole, benzimidazole, N-benzylbenzimidazole, N-(4-chlorobenzyl)benzimidazole] to release CO in human invasive ductal breast (MCF-7) cell line. In vitro experiments indicated that the compounds inhibited cell proliferation and exhibited cytotoxic effect on breast cancer cells. Moreover, side groups of the compounds enhanced the anticancer effects in MCF-7 cell line. These manganese containing CORMs gave promising results and may be used as a drug template for effective treatment of invasive ductal breast carcinoma. [GRAPHICS] .en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [112T320]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) [grant number 112T320].en_US
dc.identifier.doi10.1080/00958972.2016.1231921
dc.identifier.endpage3394en_US
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue22en_US
dc.identifier.scopus2-s2.0-84988566309en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage3384en_US
dc.identifier.urihttps://doi.org/10.1080/00958972.2016.1231921
dc.identifier.urihttps://hdl.handle.net/11616/97511
dc.identifier.volume69en_US
dc.identifier.wosWOS:000386021200007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Coordination Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhotoCORMsen_US
dc.subjectmanganese carbonyl complexesen_US
dc.subjectanticanceren_US
dc.subjectimidazoleen_US
dc.subjectbenzimidazoleen_US
dc.titleCO-releasing properties and anticancer activities of manganese complexes with imidazole/benzimidazole ligandsen_US
dc.typeArticleen_US

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