Novel immunohistochemical marker in the differential diagnosis of sex cord-stromal tumors: SF-1
| dc.contributor.author | Alpaslan Duman, Aslihan | |
| dc.contributor.author | Ates Ozdemir, Deniz | |
| dc.contributor.author | Tuncel, Ferah | |
| dc.contributor.author | Usubutun, Alp | |
| dc.contributor.author | Usubutun, Alp | |
| dc.date.accessioned | 2022-03-21T14:00:38Z | |
| dc.date.available | 2022-03-21T14:00:38Z | |
| dc.date.issued | 2022 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Aim: Sex cord-stromal tumors are relatively uncommon tumors which constitute approximately 8% of all primary ovarian neoplasms. Morphologic differentiation of non-SCST from SCSTs can be challenging due to microscopic overlap. Immunohistochemistry is beneficial in challenging cases. Inhibin and calretinin have limited sensitivity and specificity, a more sensitive marker is required. SF-1 is known as a promising immunohistochemical marker in the differentiation of SCST from non-SCST ovarian tumors. For this purpose, various non-SCSTs (metastatic and non-metastatic) having morphologic overlap with SCSTs, and multiple SCSTs were stained with SF-1 antibody to elucidate its importance in morphologically challenging cases. Materials and Methods: Twenty-three SCST, 40 non-SCSTs, and an ectopic adrenal tissue were stained with SF-1, and also the percentage and the intensity were scored. SF-1 immunoreactivity was seen in all 23 SCST with varying degrees of intensity and percentage. In contrast, non-SCSTs were negative in all regarding to SF-1. Ectopic adrenal gland tissue and ovarian stroma are positive as non-tumoral lesions. Results: In our series, SF-1 immunoreactivity was seen in all 23 SCST and ectopic adrenal tissue with varying degrees of intensity and diffuseness. In contrast, non-SCSTs were all negative concerning SF-1. In addition; we observed nuclear positivity with SF-1 in 15-75% of the sclerosing stromal tumor cells, whereas inhibin and calretinin were negative in all 4 cases. Conclusion: Our data shows that SF-1 is a nuclear, reliable and surrogate marker for all SCSTs, and can be used routinely. | en_US |
| dc.identifier.citation | Duman, A. A., Ozdemir, D. A., Tuncel, F., Usubutun, A., & Usubutun, A. (2022). Novel immunohistochemical marker in the differential diagnosis of sex cord-stromal tumors: SF-1. Annals of Medical Research, | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/56715 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Annals of Medical Research | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Novel immunohistochemical marker in the differential diagnosis of sex cord-stromal tumors: SF-1 | en_US |
| dc.type | Article | en_US |
