Comparison of hydrophobic properties of thoracic duct lymph chylomicrons from rats given different fats or oils by gavage

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dc.authoridKaya, Kürsat/0000-0002-6353-7791
dc.authoridÇANKAYA, ÖZLEM/0000-0002-7407-2352
dc.authorwosidGüldür, Tayfun/AAA-7088-2021
dc.authorwosidKaya, Kürsat/ABG-2848-2020
dc.authorwosidÇANKAYA, ÖZLEM/ABH-9456-2020
dc.contributor.authorKaya, K.
dc.contributor.authorIsikgil, O.
dc.contributor.authorGuldur, T.
dc.date.accessioned2024-08-04T20:39:40Z
dc.date.available2024-08-04T20:39:40Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractLipoprotein aggregation is generated by hydrophobic nature of lipoproteins that is known to be one of the causes of atherosclerosis. Low density lipoproteins (LDL) has been extensively studied in this respect but not chylomicrons. There is strong evidence that post-prandial triacylglycerol-rich lipoproteins are atherogenic. Because biophysical properties of lipoproteins are largely determined by their lipid compositions, hydrophobic nature of thoracic lymph duct chylomicrons obtained from rats given different fats or oils by gavage was investigated by vortexing-induced aggregation and hydrophobic interaction chromatography. Contrary to LDL, vortexing did not cause aggregation in chylomicrons. Vortexing of fish oil and butter chylomicrons resulted in more prominent reduction in absorbances compared with chylomicrons from other sources that might indicate less micelle stability. Hydrophobic interaction chromatography of fish oil, palm oil and olive oil chylomicrons yielded three fractions, whereas that of sunflower, margarine and butter chylomicrons gave rise to two fractions. These results suggest that surface hydrophobicity of chylomicrons might be heterogenous. Our results also demonstrate that fish oil chylomicrons have less hydrophobicity and lower stability against vortexing compared with chylomicrons from other sources. Considering beneficial effects of fish oil in cardiovascular health, less hydrophobicity together with lower stability might provide an additional atherogeneicity index for lipoproteins.en_US
dc.description.sponsorshipInonu University, Scientific Research Projects Unit [2008/72, 2008/73]en_US
dc.description.sponsorshipThis work was supported by Inonu University, Scientific Research Projects Unit (Grant No: 2008/72 and 2008/73).en_US
dc.identifier.doi10.1111/jpn.12127
dc.identifier.endpage595en_US
dc.identifier.issn0931-2439
dc.identifier.issn1439-0396
dc.identifier.issue3en_US
dc.identifier.pmid24112055en_US
dc.identifier.scopus2-s2.0-84899922128en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage587en_US
dc.identifier.urihttps://doi.org/10.1111/jpn.12127
dc.identifier.urihttps://hdl.handle.net/11616/96434
dc.identifier.volume98en_US
dc.identifier.wosWOS:000335398200024en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Animal Physiology and Animal Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectlipidsen_US
dc.subjectchylomicronsen_US
dc.subjectatherosclerosisen_US
dc.subjectaggregationen_US
dc.subjecthydrophobicityen_US
dc.subjectchromatographyen_US
dc.titleComparison of hydrophobic properties of thoracic duct lymph chylomicrons from rats given different fats or oils by gavageen_US
dc.typeArticleen_US

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