Preventive effects of Resveratrol against azoxymethane-induced testis injury in rats

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dc.authoridOtlu, Onder/0000-0001-5958-7609
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authorwosidOtlu, Onder/W-3887-2018
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.contributor.authorKurus, M.
dc.contributor.authorKarabulut, A. Bay
dc.contributor.authorTaslidere, E.
dc.contributor.authorOtlu, O.
dc.date.accessioned2024-08-04T20:42:33Z
dc.date.available2024-08-04T20:42:33Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTo evaluate the protective effects of Resveratrol (RES) on azoxymethane (AOM)-induced testicular damage using histopathology and biochemical analyses, 28 male rats were randomly divided into four groups. Groups were control, RES, AOM and ARES. At the end of the 7 weeks, following routine tissue processing procedure, testis sections were stained with haematoxylin-eosin and Masson's trichrome. The blood samples were taken for biochemical analysis of testosterone, total oxidative stress, total antioxidant status and oxidative stress index. Degenerative changes in the seminiferous tubules such as atrophy, loss in the number of germ cells and arrested spermatogenic cell, and increase in the connective tissue of the tunica albuginea in the groups with AOM treatment were found. RES treatment (ARES) reduced the number of affected seminiferous tubules significantly (p < .05) compared to AOM alone. The testosterone levels in AOM group were significantly lower than in the control group (p < .05). The total oxidative stress levels were significantly higher in AOM group compared to control group (p < .05). The total antioxidant status levels in ARES group were significantly higher than in the AOM group (p < .05). This study results suggest that an antioxidant like Resveratrol may be useful for decreasing the harmful effects of azoxymethane.en_US
dc.identifier.doi10.1111/and.12674
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue6en_US
dc.identifier.pmid27484696en_US
dc.identifier.scopus2-s2.0-84980350868en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.12674
dc.identifier.urihttps://hdl.handle.net/11616/97451
dc.identifier.volume49en_US
dc.identifier.wosWOS:000408624600009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantioxidanten_US
dc.subjectazoxymethaneen_US
dc.subjecthistopathologyen_US
dc.subjectresveratrolen_US
dc.subjecttestisen_US
dc.titlePreventive effects of Resveratrol against azoxymethane-induced testis injury in ratsen_US
dc.typeArticleen_US

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