Prevalence of Familial Mediterranean Fever in Children with Cryptogenic Cirrhosis

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dc.authoridVarol, İlknur fatma/0000-0001-5212-218X
dc.authoridTabel, Yilmaz/0000-0001-7359-4944
dc.authorwosidVarol, İlknur fatma/ABH-6387-2020
dc.contributor.authorVarol, Fatma Ilknur
dc.contributor.authorTabel, Yilmaz
dc.contributor.authorYologlu, Saim
dc.contributor.authorYesilada, Elif
dc.date.accessioned2024-08-04T20:50:37Z
dc.date.available2024-08-04T20:50:37Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by abdominal and chest pain and recurrent fever due to inflammation in the serosal membranes such as peritoneum, pleura and synovia. In FMF, recurrent inflammatory cytokine production may lead to cirrhosis. The aim of this study was to determine the prevalence of FMF in children with cryptogenic cirrhosis and it was found to be high, to add FMF among the etiological causes of cirrhosis. Materials and methods: This prospective cohort study conducted at the Hospital of Inonu University, Malatya, Turkey. In this study, 44 patients diagnosed with cryptogenic cirrhosis by biopsy, in the Pediatric Gastroenterology, Hepatology and Nutrition Clinic, were included, after the other reasons that may cause chronic liver disease were excluded. MEVF gene analysis was performed for all patients with cryptogenic cirrhosis. Results: FMF genetic mutation was detected in 9 (20%) of 44 patients. M694V mutation was detected in one patient (2.27%) and E148Q homozygous mutation was detected in one patient (2.27%). Various other heterozygous mutations were detected in seven other patients. Homozygous and heterozygous R202Q mutations were detected in one patient. Conclusion: We suggest that FMF plays a role in the etiologic differential diagnosis of cryptogenic cirrhosis.en_US
dc.identifier.doi10.1093/tropej/fmab019
dc.identifier.issn0142-6338
dc.identifier.issn1465-3664
dc.identifier.issue3en_US
dc.identifier.pmid34363075en_US
dc.identifier.scopus2-s2.0-85114066813en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1093/tropej/fmab019
dc.identifier.urihttps://hdl.handle.net/11616/100180
dc.identifier.volume67en_US
dc.identifier.wosWOS:000809920300044en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofJournal of Tropical Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchildrenen_US
dc.subjectchronic liver diseaseen_US
dc.subjectcryptogenic cirrhosisen_US
dc.subjectfamilial Mediterranean feveren_US
dc.titlePrevalence of Familial Mediterranean Fever in Children with Cryptogenic Cirrhosisen_US
dc.typeArticleen_US

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