Cytotoxic potential of silver, palladium, rhodium, ruthenium, and iridium complexes of a cycloheptyl-substituted lipophilic N-heterocyclic carbene ligand

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dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridTekin, Suat/0000-0002-2757-1802;
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidŞekerci, Güldeniz/IVH-2033-2023
dc.contributor.authorKaratas, Mert Olgun
dc.contributor.authorSekerci, Guldeniz
dc.contributor.authorTekin, Suat
dc.contributor.authorSandal, Suleyman
dc.contributor.authorKucukbay, Hasan
dc.date.accessioned2024-08-04T20:54:32Z
dc.date.available2024-08-04T20:54:32Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractLipophilicity is a crucial parameter for cytotoxicity of metal complexes, in many cases associated with increased activity. In the present study, we synthesized a series of N-heterocyclic carbene (NHC) complexes of different metals with a lipophilic benzimidazolium chloride to investigate and compare their cytotoxicity. Rh- (4), Ru- (5), and Ir-NHC (6) complexes of a cycloheptyl-substituted benzimidazole-based NHC ligand (1) have been prepared by transmetalation reaction between Ag-NHC and the corresponding metal compound. The newly synthesized complexes have been characterized by NMR, IR, LC-MS spectroscopy, and elemental analyses. The anti-growth effects of the newly synthesized Rh-, Ru-, and Ir-NHC complexes and previously reported NHC precursor (1), Ag- (2), and Pd-NHC (3) complexes against human breast (MCF-7), colorectal (Caco-2), ovarian (A2780), and prostate (LNCaP) cancer cell lines have been investigated by MTT assay. The results revealed that the compounds provide stronger anti-growth effects against all cell lines compared to standard drug cisplatin. Among the compounds, benzimidazolium chloride, and Ag-NHC complex showed promising activities.en_US
dc.identifier.doi10.1080/00958972.2023.2236766
dc.identifier.endpage1517en_US
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue11-12en_US
dc.identifier.scopus2-s2.0-85165455004en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1507en_US
dc.identifier.urihttps://doi.org/10.1080/00958972.2023.2236766
dc.identifier.urihttps://hdl.handle.net/11616/101479
dc.identifier.volume76en_US
dc.identifier.wosWOS:001035659900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Coordination Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Heterocyclic carbeneen_US
dc.subjectlipophilicityen_US
dc.subjectbenzimidazolium salten_US
dc.subjectsilveren_US
dc.subjectpalladiumen_US
dc.subjectrhodiumen_US
dc.subjectrutheniumen_US
dc.subjectiridiumen_US
dc.subjectcytotoxicityen_US
dc.titleCytotoxic potential of silver, palladium, rhodium, ruthenium, and iridium complexes of a cycloheptyl-substituted lipophilic N-heterocyclic carbene liganden_US
dc.typeArticleen_US

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