Combinatorial effect of zoledronic acid and irradiation on the prevention of DMBA-induced precancerogenic changes in the mammary tissues of rats

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dc.authoridsahin, nurhan/0000-0001-9487-1154
dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.authoridGurocak, Asc Prof Simay/0000-0002-3707-5183
dc.authoridince, volkan/0000-0002-0714-490X
dc.authoridtemelli, oztun/0000-0003-3471-1284
dc.authoridTuzcu, Mehmet/0000-0002-1329-3143
dc.authorwosidsahin, nurhan/ABF-8007-2020
dc.authorwosidSahin, Kazim/D-5625-2009
dc.authorwosidGurocak, Asc Prof Simay/N-3351-2014
dc.authorwosidtemelli, Oztun/ABE-6986-2020
dc.authorwosidSahin, Nurhan/D-5626-2009
dc.authorwosidince, volkan/M-7325-2017
dc.authorwosidTuzcu, Mehmet/H-2953-2018
dc.contributor.authorGurocak, Simay
dc.contributor.authorKarabulut, Aysun Bay
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorSahin, Nurhah
dc.contributor.authorTemelli, Oztun
dc.contributor.authorInce, Volkan
dc.contributor.authorSahin, Kazim
dc.date.accessioned2024-08-04T20:42:33Z
dc.date.available2024-08-04T20:42:33Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: At present, the rates of breast cancer are continuously increasing, with over a million new cases being diagnosed worldwide each year. Hence, the development of new breast cancer chemopreventive drugs with acceptable efficacy and toxicity that are suitable for use for a protracted period of time is urgently needed. The present study investigated the potential preventive effects of zoledronic acid [ZOL] and radiotherapy [RT], both alone and in combination, on precancerogenic changes on the breast tissues of females. Materials and Methods: Wistar rats were treated with 7,12-dimethylbenz [a] anthracene [DMBA] at the acute phase. Fifty female rats were divided into seven groups: Control group [I]; ZOL, group [II]; RT, group [III]; DMBA, group [IV]; DMBA + RT, group [V]; DMBA + ZOL, group [VI]; and DMBA + ZOL + RT, group [VII]. Results: The treatment of DMBA-exposed rats with ZOL and RT, both alone and in combination, successfully upregulates the transcriptional levels of Bax, caspase-3, caspase-9, p21, and BRCA 1 in mammary tissues, which may account for the elevated apoptotic activities observed and the eventual inhibition of tumor growth. The administration of RT and ZOL both alone and in combination was found to be effective for inhibiting the DMBA-induced precancerogenic changes on breast tissues and modulating the expression of apoptosis-associated proteins in the acute phase. Conclusions: The combination of RT and ZOL was more effective than either agent alone. Our results suggest that the administration of ZOL and irradiation in combination can offer maximal protection against DMBA-induced mammary precancerogenic changes.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Unit [IUBAP] [2011-95]en_US
dc.description.sponsorshipAuthors thank Inonu University Scientific Research Projects Unit [IUBAP] for supporting this study [2011-95].en_US
dc.identifier.doi10.4103/0973-1482.151427
dc.identifier.endpage649en_US
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issue2en_US
dc.identifier.pmid27461625en_US
dc.identifier.scopus2-s2.0-84979974255en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage645en_US
dc.identifier.urihttps://doi.org/10.4103/0973-1482.151427
dc.identifier.urihttps://hdl.handle.net/11616/97448
dc.identifier.volume12en_US
dc.identifier.wosWOS:000382405800036en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal of Cancer Research and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject7, 12-dimethylbenz[a] anthraceneen_US
dc.subjectbreast canceren_US
dc.subjectzoledronic acid radiotherapyen_US
dc.titleCombinatorial effect of zoledronic acid and irradiation on the prevention of DMBA-induced precancerogenic changes in the mammary tissues of ratsen_US
dc.typeArticleen_US

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