Evidence that the activities of erythrocyte free radical scavenging enzymes and the products of lipid peroxidation ape increased in different forms of schizophrenia

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dc.authoridOZYURT, Huseyin/0000-0003-2327-4082
dc.authorwosidUz, Efkan/B-2943-2016
dc.authorwosidOZYURT, Huseyin/N-4351-2015
dc.contributor.authorHerken, H
dc.contributor.authorUz, E
dc.contributor.authorÖzyurt, H
dc.contributor.authorSögüt, S
dc.contributor.authorVirit, O
dc.contributor.authorAkyol, Ö
dc.date.accessioned2024-08-04T20:12:16Z
dc.date.available2024-08-04T20:12:16Z
dc.date.issued2001
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn order to examine antioxidant status and lipid peroxidation in schizophrenia patients, activities of three free radical scavenging enzymes (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT)), and the level of thiobarbituric acid-reactive substances (TBARS) as an index of lipid peroxidation have been studied in red blood cells. Schizophrenic patients were divided into three groups (disorganized (n = 21), paranoid (n = 26) and residual types (n = 18)) to determine differences between subgroups. SOD, CAT and GSH-Px activities in the control group were found to be 1461.0 +/- 248.6 U g(-1) Hb, 148.2 +/- 59.3 k g(-1) Hb and 25.87 +/- 4.25 U g(-1) Hb, respectively. We found no significant differences in SOD activities between study and control groups. There was a significant increase in SOD activity in the residual group compared to the paranoid group (P < 0.005). CAT activity was found to be increased in disorganized (148%), paranoid (147%), and residual (165%) groups compared to the control group. GSH-Px activity was markedly increased in the study groups except the paranoid group. Statistically significant (3-4 fold) increases in TBARS levels of red blood cells were found in all the study groups. It is proposed that antioxidant status may be changed in schizophrenia and thus may induce lipid peroxidation. Therefore, oxidative stress may have a pathophysiological role in all the subtypes of schizophrenia.en_US
dc.identifier.doi10.1038/sj.mp.4000789
dc.identifier.endpage73en_US
dc.identifier.issn1359-4184
dc.identifier.issn1476-5578
dc.identifier.issue1en_US
dc.identifier.pmid11244487en_US
dc.identifier.scopus2-s2.0-0035133525en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage66en_US
dc.identifier.urihttps://doi.org/10.1038/sj.mp.4000789
dc.identifier.urihttps://hdl.handle.net/11616/93318
dc.identifier.volume6en_US
dc.identifier.wosWOS:000165952400012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofMolecular Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectschizophreniaen_US
dc.subjectthiobarbituric acid-reactive substances (TBARS)en_US
dc.subjectsuperoxide dismutase (SOD)en_US
dc.subjectglutathione peroxidase (GSH-Px)en_US
dc.subjectcatalase (CAT)en_US
dc.subjectfree radicalsen_US
dc.titleEvidence that the activities of erythrocyte free radical scavenging enzymes and the products of lipid peroxidation ape increased in different forms of schizophreniaen_US
dc.typeArticleen_US

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