Melatonin Protects Inner Ear Against Radiation Damage in Rats

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dc.authoridGurocak, Asc Prof Simay/0000-0002-3707-5183
dc.authoridBAHAR, LEYLA/0000-0002-6910-6167
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridBAHAR, LEYLA/0000-0002-6910-6167
dc.authoridSIMSEK, GOKCE/0000-0001-5281-0986
dc.authorwosidGurocak, Asc Prof Simay/N-3351-2014
dc.authorwosidBAHAR, LEYLA/P-3890-2015
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidBAHAR, LEYLA/Y-3908-2019
dc.authorwosidSIMSEK, GOKCE/F-1019-2016
dc.contributor.authorKaraer, Isil
dc.contributor.authorSimsek, Gokce
dc.contributor.authorGul, Mehmet
dc.contributor.authorBahar, Leyla
dc.contributor.authorGurocak, Simay
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorNuransoy, Ayse
dc.date.accessioned2024-08-04T20:41:13Z
dc.date.available2024-08-04T20:41:13Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives/Hypothesis: To examine the effects of N-acetyl-5-methoxytryptamine (melatonin) on radiation-induced inner ear damage. Study Design: An experimental animal model. Methods: Forty rats were randomized into five groups, as follows: 1) melatonin and then radiotherapy group (n = 8), which received intraperitoneal (i.p.) melatonin (5 mg/kg) followed by irradiation 30 minutes later; 2) radiotherapy and then melatonin group (n = 8), which received irradiation with i.p. melatonin (5 mg/kg) 30 minutes later; 3) melatonin group (n = 8), which received i.p. melatonin (5 mg/kg); 4) radiotherapy group (n = 8), which underwent only irradiation; 5) and the control group (n = 8), which received i.p. 0.9% NaCl. The medications and irradiation were administered for 5 days. All rats underwent the distortion product otoacoustic emission (DPOAE) test before and 10 days after the experiment. The middle ears of the rats were excised, and assessment of tissue alterations in the organs of Corti, spiral ganglions, and stria vascularis were compared among the groups. Results: In the radiotherapy group, the DPOAE amplitudes at frequencies of 4000 to 6000 Hz were significantly decreased when compared with the controls. The DPOAE amplitudes both in the melatonin and then radiotherapy group and the radiotherapy and then melatonin group exhibited better values than they did in the radiotherapy group. Histopathological evidence of damage to the organs of Corti, spiral ganglions, and stria vascularis damage was markedly reduced in both these two groups when compared to the radiotherapy group. Conclusion: These results indicate that melatonin may have significant ameliorative effects on cochlear damage secondary to ionizing radiation.en_US
dc.identifier.doi10.1002/lary.25376
dc.identifier.endpageE349en_US
dc.identifier.issn0023-852X
dc.identifier.issn1531-4995
dc.identifier.issue10en_US
dc.identifier.pmid25994110en_US
dc.identifier.scopus2-s2.0-84942821709en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE345en_US
dc.identifier.urihttps://doi.org/10.1002/lary.25376
dc.identifier.urihttps://hdl.handle.net/11616/96995
dc.identifier.volume125en_US
dc.identifier.wosWOS:000363386300004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofLaryngoscopeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInner earen_US
dc.subjectmelatoninen_US
dc.subjectotoacoustic emissionen_US
dc.subjectradiotherapyen_US
dc.titleMelatonin Protects Inner Ear Against Radiation Damage in Ratsen_US
dc.typeArticleen_US

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