Protective Effects of Caffeic Acid Phenethyl Ester Against Carbon Tetrachloride-induced Testicular Damage in Rats: A Histological Study

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dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.contributor.authorGulhan, Belemir
dc.contributor.authorTaslidere, Elif
dc.contributor.authorVardi, Nigar
dc.contributor.authorTaslidere, Asli
dc.contributor.authorElbe, Hulya
dc.date.accessioned2024-08-04T20:11:41Z
dc.date.available2024-08-04T20:11:41Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Carbon tetrachloride (CCI4) is a volatile organic chemical agent that can cause damage to many tissues. Caffeic acid phenethyl ester (CAPE), which is structurally similar to flavonoids, is an active component of honeybee propolis. CAPE is known for its antitoxic, antioxidant, and antiinflammatory effects. In this study, we aimed to investigate the effects of CAPE against testicular damage caused by CCI4. Materials and Methods: Twenty-eight Wistar albino rats were divided into 4 groups (n=7) as, Group 1: control (5% ethanol, 1 mL/day/ip), Group 2: olive oil (0.5 mL/day over/ip), Group 3: CCI4 (0.5 mL/kg over/ip), Group 4: CCI4+CAPE (10 mu mol/kg/day/ip). Tissue samples collected at the end of the experiment were detected in 10% formaldehyde and embedded in paraffin. Five-micron-thick sections taken from paraffin blocks were stained with hematoxylin-eosin. To evaluate testicular damage, 100 tubules from each section were randomly examined at 20x magnification under a light microscope and classified as intact, atrophic, and degenerated tubules. Sections were examined by using Leica DFC 280 light microscope and Leica Q Win Image Analysis system (Leica Micros Imaging Solutions Ltd. Cambridge, UK). Results: The testicular sections of the control group and the olive oil group had a normal histological appearance. In the CCI4 group, 55.00 +/- 4.22% of the seminiferous tubules were intact, 25.00 +/- 2.67% were atrophic and 20.00 +/- 1.88% were degenerative. In addition, multinucleated giant cells were found in the lumen of some seminiferous tubules. In the CCI4+CAPE group, 72.14 +/- 3.91% of the tubules were intact, 16.42 +/- 2.10% were atrophic, and 11.42 +/- 2.36% were degenerative. While the number of affected tubules significantly increased in the CCI4 group compared to the control group (p<0.05), the number of affected seminiferous tubules decreased significantly in the CCI4+CAPE group compared to the CCI (4) group (p<0.05). Conclusion: We think that CAPE may be useful in reducing the damaging effects of CCI4 on the testicle.en_US
dc.identifier.doi10.4274/nkmj.galenos.2023.82474
dc.identifier.endpage21en_US
dc.identifier.issn2587-0262
dc.identifier.issue1en_US
dc.identifier.startpage17en_US
dc.identifier.trdizinid1175789en_US
dc.identifier.urihttps://doi.org/10.4274/nkmj.galenos.2023.82474
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1175789
dc.identifier.urihttps://hdl.handle.net/11616/92920
dc.identifier.volume11en_US
dc.identifier.wosWOS:001186705700002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofNamik Kemal Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCAPEen_US
dc.subjectcarbon tetrachlorideen_US
dc.subjectraten_US
dc.subjecttestisen_US
dc.titleProtective Effects of Caffeic Acid Phenethyl Ester Against Carbon Tetrachloride-induced Testicular Damage in Rats: A Histological Studyen_US
dc.typeArticleen_US

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