Hepatitis B virus genotype D prevails in patients with persistently elevated or normal ALT levels in Turkey

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dc.authorwosidCiftci, Sevgi/AAC-7679-2020
dc.authorwosidciftci, sevgi/AAL-7068-2021
dc.contributor.authorYalcin, K
dc.contributor.authorDegertekin, H
dc.contributor.authorBahcecioglu, IH
dc.contributor.authorDemir, A
dc.contributor.authorAladag, M
dc.contributor.authorYildirim, B
dc.contributor.authorHorasanli, S
dc.date.accessioned2024-08-04T20:13:40Z
dc.date.available2024-08-04T20:13:40Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The clinical relevance of hepatits B virus (HBV) genotypes are poorly understood and it is unclear if the prevalence of HBV genotypes differs with the various clinical features of HBV carriers. The aim of our study was to examine the prevalence of the HBV genotype in a group of patients with chronic hepatitis B, compared to a group with chronic inactive hepatits B surface antigen (HbsAg) carriers. Patients and Methods: HBV genotypes were determined in 32 patients with chronic hepatitis B and in 12 chronic inactive HBsAg carriers. 35 males and nine females with a mean age of 33.95 +/- 13.04 were studied. Serum samples were examined for the presence of HBV DNA by polymerase chain reaction (PIER). Samples negative in first round PCR were further amplified with nested PCR. The PCR product was sequenced with the Cy5/5.5 dye primer kit on a Long Read Tower automated DNA sequencer. Results: HBV DNA was detectable in 29 (66%) and 44 (100%) patients by the PCR with universal primers and nested-PCR, respectively. All patients were found to be infected with HBV genotype D. Genotype D was the only detected type found in different clinical forms of chronic HBV infection, in all hepatitis B e antigen (HbeAg)-positive and negative patients, in at[ patients who had elevated or normal alanine transaminase (ALT) Levels and in all ages. Conclusion: In the present study we could not find any association between genotype D and distinct clinical phenotypes. Genotype D is the predominant type among hepatitis B carriers residing in our region and is not associated with more severe liver diseases. This genotype did not influence clinical manifestations in carriers with chronic hepatitis B virus infection. However, additional Large-scale longitudinal studies are needed to find the relationship of HBV genotypes to liver disease severity and clinical outcomes.en_US
dc.identifier.doi10.1007/s15010-004-3010-7
dc.identifier.endpage29en_US
dc.identifier.issn0300-8126
dc.identifier.issn1439-0973
dc.identifier.issue1en_US
dc.identifier.pmid15007739en_US
dc.identifier.scopus2-s2.0-1142273151en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage24en_US
dc.identifier.urihttps://doi.org/10.1007/s15010-004-3010-7
dc.identifier.urihttps://hdl.handle.net/11616/93773
dc.identifier.volume32en_US
dc.identifier.wosWOS:000189037700006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofInfectionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSurface-Antigenen_US
dc.subjectHbv Infectionen_US
dc.subjectCore Promoteren_US
dc.subjectPhylogenetic Relatednessen_US
dc.subjectNucleotide-Sequenceen_US
dc.subjectCentral-Americaen_US
dc.subjectPrecore Regionen_US
dc.subjectLiver-Damageen_US
dc.subjectStrainsen_US
dc.subjectOriginen_US
dc.titleHepatitis B virus genotype D prevails in patients with persistently elevated or normal ALT levels in Turkeyen_US
dc.typeArticleen_US

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