High-fructose corn syrup causes vascular dysfunction associated with metabolic disturbance in rats: Protective effect of resveratrol

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dc.authoriduludağ, mecit orhan/0000-0001-9837-1317
dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.authoridAkar, Fatma/0000-0002-5432-0304
dc.authoridTuzcu, Mehmet/0000-0002-1329-3143
dc.authorwosiduludağ, mecit orhan/AHH-4029-2022
dc.authorwosidSahin, Kazim/D-5625-2009
dc.authorwosidAkar, Fatma/D-1650-2018
dc.authorwosidTuzcu, Mehmet/H-2953-2018
dc.contributor.authorAkar, Fatma
dc.contributor.authorUludag, Orhan
dc.contributor.authorAydin, Ali
dc.contributor.authorAytekin, Yasin Atacan
dc.contributor.authorElbeg, Sehri
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorSahin, Kazim
dc.date.accessioned2024-08-04T20:35:54Z
dc.date.available2024-08-04T20:35:54Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHigh-fructose corn syrup (HFCS) is used in many prepared foods and soft drinks. However, limited data is available on the consequences of HFCS consumption on metabolic and cardiovascular functions. This study was, therefore, designed to assess whether HFCS drinking influences the endothelial and vascular function in association with metabolic disturbances in rats. Additionally, resveratrol was tested at challenge with HFCS. We investigated the effects of HFCS (10% and 20%) and resveratrol (50 mg/l) beverages on several metabolic parameters as well as endothelial relaxation, vascular contractions, expressions of endothelial nitric oxide synthase (eNOS), sirtuin 1 (SIRT1), gp91(phox) and p22(phox) proteins and superoxide generation in the aortas. Consumption of HFCS (20%) increased serum triglyceride, VLDL and insulin levels as well as blood pressure. Impaired relaxation to acetylcholine and intensified contractions to phenylephrine and angiotensin II were associated with decreased eNOS and SIRT1 whereas increased gp91(phox) and p22(phox) proteins, along with provoked superoxide production in the aortas from HFCS-treated rats. Resveratrol supplementation efficiently restored HFCS-induced deteriorations. Thus, intake of HFCS leads to vascular dysfunction by decreasing vasoprotective factors and provoking oxidative stress in association with metabolic disturbances. Resveratrol has a protective potential against the harmful consequences of HFCS consumption. (C) 2012 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipGazi University Research Fund [BAP 02/2010-26]en_US
dc.description.sponsorshipThis study was supported partially by a grant from Gazi University Research Fund (BAP 02/2010-26).en_US
dc.identifier.doi10.1016/j.fct.2012.03.061
dc.identifier.endpage2141en_US
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.issue6en_US
dc.identifier.pmid22465803en_US
dc.identifier.scopus2-s2.0-84861444769en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2135en_US
dc.identifier.urihttps://doi.org/10.1016/j.fct.2012.03.061
dc.identifier.urihttps://hdl.handle.net/11616/95667
dc.identifier.volume50en_US
dc.identifier.wosWOS:000305719700045en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofFood and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHigh-fructose corn syrupen_US
dc.subjectResveratrolen_US
dc.subjectVascular dysfunctionen_US
dc.subjectSirtuinen_US
dc.subjectNitric oxideen_US
dc.subjectNADPH oxidaseen_US
dc.titleHigh-fructose corn syrup causes vascular dysfunction associated with metabolic disturbance in rats: Protective effect of resveratrolen_US
dc.typeArticleen_US

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