Time estimations by network of beta globin gene cluster haplotypes linked with Hb D-Los Angeles [?121 (GH4) Glu ? Gln GAA ? CAA] mutation in the world populations

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dc.authoridOZTURK, Onur/0000-0003-3404-4135;
dc.authorwosidOZTURK, Onur/HLH-4990-2023
dc.authorwosidATALAY, AYFER/HKO-1963-2023
dc.authorwosidArıkan, Sanem/ABI-6170-2020
dc.contributor.authorOzturk, Onur
dc.contributor.authorArikan, Sanem
dc.contributor.authorAtalay, Ayfer
dc.contributor.authorAtalay, Erol O.
dc.date.accessioned2024-08-04T20:45:32Z
dc.date.available2024-08-04T20:45:32Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground beta-Globin gene cluster haplotypes associated with the Hb D-Los Angeles mutation have been reported in many different locations in different populations including Italy, Iran, Thailand, Belgium, Mexico, Holland, and Turkey. In this study, we have identified genetic relationships and formation periods between the haplotypes reported in the world regarding the Hb D-Los Angeles. Methods We comparatively analyzed the RFLP (restriction fragment length polymorphism) data in Denizli region and world populations using Arlequin 3.5 statistical software program. The data obtained from the Arlequin software were then entered into the Phylogenetic Network software to calculate the age estimates and to discover possible links between the haplotypes. Results We observed the frequencies of the beta-globin gene haplotypes for the seven polymorphic restriction sites around the world and calculated the estimated time of haplotypes using Network software on the basis of ancestral haplotypes. We performed the phylogenetic network analysis of the haplotypes linked with Hb D-Los Angeles mutation by processing the data of frequency and age estimations with Network software. Conclusion Our period of time results suggests that HAP1 was formed before modern human migration to Asia and/or independent origin of the Hb D-Los Angeles mutation from other populations. Considering that the population in Denizli region started the Hb D-Los Angeles mutation past about 40,000 years ago, it can be said that HAP1, HAP15, and HAP21 belong to the gene pool with an external effect. Our period of time results of HAP6 is compatible with published dating results.en_US
dc.identifier.doi10.1002/mgg3.499
dc.identifier.endpage1187en_US
dc.identifier.issn2324-9269
dc.identifier.issue6en_US
dc.identifier.pmid30417580en_US
dc.identifier.scopus2-s2.0-85056335455en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1181en_US
dc.identifier.urihttps://doi.org/10.1002/mgg3.499
dc.identifier.urihttps://hdl.handle.net/11616/98533
dc.identifier.volume6en_US
dc.identifier.wosWOS:000454205500032en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofMolecular Genetics & Genomic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthaplotypeen_US
dc.subjectHb D-Los Angelesen_US
dc.subjectphylogenetic network analysisen_US
dc.subjecttime estimateen_US
dc.subjectbeta-globin gene clusteren_US
dc.titleTime estimations by network of beta globin gene cluster haplotypes linked with Hb D-Los Angeles [?121 (GH4) Glu ? Gln GAA ? CAA] mutation in the world populationsen_US
dc.typeArticleen_US

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