The influence of severe obesity on non-invasive ventilation (NIV) strategies and responses in patients with acute hypercapnic respiratory failure attacks in the ICU

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dc.authoridGulbas, Gazi/0000-0002-9435-8307
dc.authoridOzkaya, Sevket/0000-0002-8697-4919;
dc.authorwosidGulbas, Gazi/ABI-5182-2020
dc.authorwosidOzkaya, Sevket/AAE-4521-2020
dc.authorwosidYildirim, Fatma/AET-5783-2022
dc.contributor.authorGursel, G.
dc.contributor.authorAydogdu, M.
dc.contributor.authorGulbas, G.
dc.contributor.authorOzkaya, S.
dc.contributor.authorTasyurek, S.
dc.contributor.authorYildirim, F.
dc.date.accessioned2024-08-04T20:32:42Z
dc.date.available2024-08-04T20:32:42Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. Obesity rates are increasing in the general population and are also prevalent in intensive care units (ICUs). Patients are sometimes admitted to ICUs for hypercapnic respiratory failure or cor pulmonale, but more often, they are admitted for pneumonia, excessive daytime sleepiness, heart failure, chronic obstructive pulmonary disease (COPD), asthma attacks or pulmonary embolism, and hypercapnic respiratory failure is coincidentally noticed during this period. The optimal noninvasive mechanical ventilation strategy is often not used during ICU treatment. The aim of this study was to assess the differences between non-invasive ventilation (NIV) strategies and the outcomes of obese and non-obese patients with acute hypercapnic respiratory failure. Methods. In this retrospective cohort study, 73 patients who were ventilated with a face mask were studied. Patients were divided into two groups: obese (BMI>35 kg/m(2)) and non-obese (BMI<35 kg/m(2)), and the differences between these two groups in necessary pressure, volume, mode, ventilator and time to reduce PaCO2 <50 mmHg were investigated. Results. The mean age of the patients was 66 +/- 14 years, and the mean admission APACHE II score was 18 +/- 4. Forty-one (56%) of the patients were female. For the obese patients, the reason for ICU admission was more frequently pulmonary edema and less frequently pulmonary infections, which was significantly different (P=0.003 and 0.043, respectively) than the rates for the non-obese patients. While there was no significant difference across the groups between the ventilators, modes and inspiratory pressure levels, obese patients required higher end-expiratory pressure levels and more time to reduce their PaCO2 levels below 50 mmHg than non-obese patients. The lengths of NW and ICU stay and incubation and the mortality rates were similar in both groups. Conclusion. These results suggest that improvement in hypercapnia in obese patients may require higher PEEP levels and longer times than that of non-obese patients during acute hypercapnic respiratory failure attack. (Minerva Anestesiol 2011;77:17-25)en_US
dc.identifier.endpage25en_US
dc.identifier.issn0375-9393
dc.identifier.issn1827-1596
dc.identifier.issue1en_US
dc.identifier.pmid21273965en_US
dc.identifier.scopus2-s2.0-79951488064en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage17en_US
dc.identifier.urihttps://hdl.handle.net/11616/95253
dc.identifier.volume77en_US
dc.identifier.wosWOS:000287296600006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofMinerva Anestesiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypoventilationen_US
dc.subjectRespiration, artificialen_US
dc.subjectObesityen_US
dc.subjectObesity hypoventilation syndromeen_US
dc.subjectSleep apnea, obstructiveen_US
dc.titleThe influence of severe obesity on non-invasive ventilation (NIV) strategies and responses in patients with acute hypercapnic respiratory failure attacks in the ICUen_US
dc.typeArticleen_US

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