Elevated Oxidative Stress Markers and its Relationship With Endothelial Dysfunction in Behcet Disease

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dc.authoridAkaycan, Jülide/0000-0002-9174-6777
dc.authoridCansel, Mehmet/0000-0003-4740-4371
dc.authoridPekdemir, Hasan/0000-0002-4913-5120;
dc.authorwosidErmis, Necip/A-5184-2018
dc.authorwosidÇUĞLAN, bilal/AAP-8878-2021
dc.authorwosidAkaycan, Jülide/ABI-2397-2020
dc.authorwosidCansel, Mehmet/ABI-6324-2020
dc.authorwosidPekdemir, Hasan/ABI-6096-2020
dc.authorwosidErmis, Necip/HJP-7061-2023
dc.contributor.authorAcikgoz, Nusret
dc.contributor.authorErmis, Necip
dc.contributor.authorYagmur, Julide
dc.contributor.authorCansel, Mehmet
dc.contributor.authorKarincaoglu, Yelda
dc.contributor.authorAtas, Halil
dc.contributor.authorCuglan, Bilal
dc.date.accessioned2024-08-04T20:32:46Z
dc.date.available2024-08-04T20:32:46Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBehcet's disease (BD) is a multisystemic disorder characterized by endothelial dysfunction. However, the relationship between oxidative stress and endothelial function has not been clearly shown. We investigated the relationship between oxidative stress markers and endothelial function in patients with BD. Patients with BD (n = 40) having active disease and sex-and age-matched 40 controls were included. Endothelial function was assessed by flow-mediated dilatation (FMD) technique. Serum gammaglutamyltransferase (GGT) and high-sensitive C-reactive protein levels (hsCRP) were measured in all participants. Brachial artery FMD was significantly lower in patients with BD than in controls. Gamma-glutamyltransferase and hsCRP levels were higher in patients with BD than in controls. Also, GGT and hsCRP levels were inversely correlated with endothelial function. Oxidative stress markers are elevated in patients with BD having active disease. This may be one of the reasons behind the vasculitis in active BD.en_US
dc.identifier.doi10.1177/0003319710382417
dc.identifier.endpage300en_US
dc.identifier.issn0003-3197
dc.identifier.issn1940-1574
dc.identifier.issue4en_US
dc.identifier.pmid20947865en_US
dc.identifier.scopus2-s2.0-79953847288en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage296en_US
dc.identifier.urihttps://doi.org/10.1177/0003319710382417
dc.identifier.urihttps://hdl.handle.net/11616/95292
dc.identifier.volume62en_US
dc.identifier.wosWOS:000289264100003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofAngiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet's diseaseen_US
dc.subjectendothelial dysfunctionen_US
dc.subjectgamma-glutamyltransferaseen_US
dc.subjecthigh-sensitive C-reactive proteinen_US
dc.subjectoxidative stressen_US
dc.titleElevated Oxidative Stress Markers and its Relationship With Endothelial Dysfunction in Behcet Diseaseen_US
dc.typeArticleen_US

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