Intravesical hyaluronic acid and chondroitin sulfate alone and in combination for urinary tract infection: Assessment of protective effects in a rat model

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dc.authoridDuman, Yucel/0000-0002-9090-2096
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468;
dc.authorwosidDuman, Yucel/AAU-6221-2020
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidYAKUPOGULLARI, YUSUF/F-3966-2011
dc.contributor.authorTasdemir, Seda
dc.contributor.authorTasdemir, Cemal
dc.contributor.authorVardi, Nigar
dc.contributor.authorYakupogullari, Yusuf
dc.contributor.authorDuman, Yucel
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorSagir, Mustafa
dc.date.accessioned2024-08-04T20:36:14Z
dc.date.available2024-08-04T20:36:14Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To determine the protective effects of hyaluronic acid and chondroitin sulfate in treating urinary tract infections in a rat model. Methods: A total of 28 rats, which were induced with urinary tract infections through intravesical administration of Escherichia coli, were included in the study. By random selection, they were equally divided into four groups as control (no treatment), hyaluronic acid, chondroitin sulfate and hyaluronic acid + chondroitin sulfate. Bacteriological cultures of the urine and bladder tissue samples were carried out, and the data for each group were statistically compared. Results: In the urine cultures, there were significant differences in median bacterial growth rates in hyaluronic acid (5 x 103 cfu/mL) and chondroitin sulfate (1 x 104 cfu/mL) groups relative to the control group (5 x 104 cfu/mL). However, a significantly lower rate of bacterial colony growth was observed in the hyaluronic acid + chondroitin sulfate group (8 x 102 cfu/mL; P < 0.05). In the bladder tissues, statistically significant decreases in median bacterial growth rates were detected in the hyaluronic acid and hyaluronic acid + chondroitin sulfate groups (both 0 cfu/mg tissue; P < 0.05). Also, transitional epithelium damage decreased in the treatment groups. However, this effect was prominent in hyaluronic acid + chondroitin sulfate group. Conclusion: Our experimental findings show that the hyaluronic acid + chondroitin sulfate combination has a potential benefit in reducing the bacterial load in urine and the thickness of the transitional epithelium.en_US
dc.identifier.doi10.1111/j.1442-2042.2012.03109.x
dc.identifier.endpage1112en_US
dc.identifier.issn0919-8172
dc.identifier.issn1442-2042
dc.identifier.issue12en_US
dc.identifier.pmid22852837en_US
dc.identifier.scopus2-s2.0-84870295707en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1108en_US
dc.identifier.urihttps://doi.org/10.1111/j.1442-2042.2012.03109.x
dc.identifier.urihttps://hdl.handle.net/11616/95869
dc.identifier.volume19en_US
dc.identifier.wosWOS:000311611700015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbladder instillationsen_US
dc.subjectchondroitin sulfateen_US
dc.subjecthyaluronic aciden_US
dc.subjecturinary tract infectionen_US
dc.titleIntravesical hyaluronic acid and chondroitin sulfate alone and in combination for urinary tract infection: Assessment of protective effects in a rat modelen_US
dc.typeArticleen_US

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