Reduction of peritoneal adhesions by sustained and local administration of epidermal growth factor

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dc.authoridKIRAN, TUGBA RAIKA/0000-0002-3724-0249
dc.authoridHasirci, Nesrin/0000-0002-4497-0194
dc.authoridUĞURALP, SEMA/0000-0002-7628-0550
dc.authoridKıran, Tugba Raika/0000-0002-3724-0249
dc.authoridkiziltay, aysel/0000-0001-7515-2760
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridAkin, Melih/0000-0001-9269-8001
dc.authorwosidKIRAN, TUGBA RAIKA/AAA-8224-2021
dc.authorwosidHasirci, Nesrin/I-4754-2018
dc.authorwosidUĞURALP, SEMA/ABH-6309-2020
dc.authorwosidKıran, Tugba Raika/HFZ-9643-2022
dc.authorwosidkiziltay, aysel/ABI-2252-2020
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.contributor.authorUguralp, S.
dc.contributor.authorAkin, M.
dc.contributor.authorKarabulut, A. Bay
dc.contributor.authorHarma, B.
dc.contributor.authorKiziltay, Aysel
dc.contributor.authorKiran, T. R.
dc.contributor.authorHasirci, N.
dc.date.accessioned2024-08-04T20:30:39Z
dc.date.available2024-08-04T20:30:39Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPrevious studies have shown epidermal growth factor (EGF) facilitate peritoneal membrane healing by augmenting cell adhesion and migration. The objective of this study was to show the effect of sustained and local administration of EGF on peritoneal adhesion. Fourty-two rats were divided into six groups: control 7 and 14, gelatin 7 and 14, and EGF 7 and 14. Adhesions were created by scraping the cecum with mesh gause followed by application of absolute alcohol and placement of silk suture in the parietal peritoneum. The anterior walls of the intestines were covered with 5 x 5 cm unloaded, and EGF loaded gelatin films in the gelatin and EGF groups, respectively. The rats were killed on days 7 and 14 to assess the adhesion occurring, and for biochemical examination. The mean adhesion grades of EGF groups were significantly lower than in the other groups (P < 0.008). The mean adenosine deaminase (ADA) measurements of EGF 7 group were lower than in the gelatin 7 and control 7 groups but the difference was not significant (P > 0.008). The mean ADA measurements in the 14 days groups were as follows: control 14 < EGF 14 < gelatin 14 groups. The mean ADA measurements between 14 days groups did not significantly differ from each other (P > 0.008). The mean hydroxyproline measurements did not differ among the groups (P > 0.008). EGF decreased intestinal adhesion in our study. EGF has important roles in DNA synthesis and cell proliferation. Further studies are required to determine the exact mechanism by which EGF lowers the efficiency of intestinal adhesion.en_US
dc.identifier.doi10.1007/s00383-007-2059-7
dc.identifier.endpage197en_US
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue2en_US
dc.identifier.pmid17985134en_US
dc.identifier.scopus2-s2.0-38549139264en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage191en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-007-2059-7
dc.identifier.urihttps://hdl.handle.net/11616/94441
dc.identifier.volume24en_US
dc.identifier.wosWOS:000252676000010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectperitoneal adhesionsen_US
dc.subjectEGFen_US
dc.subjectpreventionen_US
dc.titleReduction of peritoneal adhesions by sustained and local administration of epidermal growth factoren_US
dc.typeArticleen_US

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