Delta Neutrophil Index as a Diagnostic Marker of Neonatal Sepsis

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dc.authorwosidMELEKOGLU, Nuriye Aslı/AFT-0402-2022
dc.authorwosidYaşar, Şeyma/ABI-8055-2020
dc.contributor.authorMelekoglu, Nuriye Asli
dc.contributor.authorYasar, Seyma
dc.contributor.authorKeskin, Mehmet
dc.date.accessioned2024-08-04T20:49:23Z
dc.date.available2024-08-04T20:49:23Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective Sepsis diagnosis is challenging due to nonspecific symptomatology in newborns. Timely diagnosis is essential for reducing sepsis-related morbidity and mortality. This study was performed to determine the diagnostic value of the delta neutrophil index (DNI) for detection of neonatal sepsis and to compare its efficacy with other conventional markers. Methods This study was conducted at a tertiary hospital in newborns with confirmed sepsis (n = 59), suspected sepsis (n = 46), and in age- and weight-matched controls (n = 49). DNI, white blood cell count, C-reactive protein (CRP) level, and platelet measurements were determined, and blood cultures were performed at the onset of symptoms. Results The mean DNI was significantly higher in confirmed and clinical sepsis groups compared with the control group. (6.9 +/- 9.3, 1.9 +/- 2.1, and 0.4 +/- 0.5, respectively, p < 0.001). ROC curve analysis also showed that the combination of DNI and CRP had the highest sensitivity (86%), specificity (100%), and positive predictive value (100%) for predicting neonatal sepsis. DNI values were significantly higher in nonsurvivors (p < 0.05). Conclusion DNI could be used as a reliable diagnosticmarker for neonatal sepsis, and high DNI could predict sepsis development and unfavorable outcomes. The diagnostic capability of DNI may be increased by assessing CRP measurements simultaneously.en_US
dc.identifier.doi10.1055/s-0041-1726118
dc.identifier.endpage105en_US
dc.identifier.issn1305-7707
dc.identifier.issn1305-7693
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85101883782en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage99en_US
dc.identifier.urihttps://doi.org/10.1055/s-0041-1726118
dc.identifier.urihttps://hdl.handle.net/11616/99796
dc.identifier.volume16en_US
dc.identifier.wosWOS:000621594600003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofJournal of Pediatric Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdelta neutrophil indexen_US
dc.subjectsepsisen_US
dc.subjectnewbornen_US
dc.titleDelta Neutrophil Index as a Diagnostic Marker of Neonatal Sepsisen_US
dc.typeArticleen_US

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