Synthesis, characterization, and investigation of antiproliferative activity of novel Ag (I)-N-Heterocyclic Carbene (NHC) compounds

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dc.authoridŞAHİN-BÖLÜKBAŞI, Serap/0000-0003-1057-2558;
dc.authorwosidŞAHİN-BÖLÜKBAŞI, Serap/ABJ-7836-2022
dc.authorwosidŞAHİN, Neslihan/F-6402-2019
dc.contributor.authorCevik-Yildiz, Esranur
dc.contributor.authorSahin, Neslihan
dc.contributor.authorSahin-Bolukbasi, Serap
dc.date.accessioned2024-08-04T20:46:45Z
dc.date.available2024-08-04T20:46:45Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to present the synthesis, characterization, and investigation of the antiproliferative activity of new metal N-Heterocyclic Carbene (NHC) salts (1a-c) and their Ag(I) complexes (2a-c). All synthesized compounds were characterized using elemental analysis, LC-MS, FT-IR,H- 1 NMR, and C-13 NMR spectroscopy techniques. Salts and complexes were tested for antiproliferative activities on human breast and prostate cancer cell lines (MCF-7, MDA-MB-23, DU-145) and L-929 normal cells for 24 h, 48 h and 72 h using MTT assays. The Ag(I)-NHC complexes (2a c) showed dose and time-dependent cytotoxic activity against all cell lines. MDA-MB-231 and MCF-7 human breast carcinoma cells were the most sensitive to displaying IC50 lower than 1 mu M at all time points for 2a and 2b complexes respectively. The IC(50)s for Ag(I)-NHC were higher in normal cells especially compared to the breast cancer cells, suggesting that complexes possessed noteworthy selectivity for human breast cancer cells. Complex 2a showed high selectivity (>= 13-fold) for MDA-MB-231 breast cancer cells at all time points. These results also demonstrated that complex 2b has 4-7-fold selectivity against MCF-7 breast cancer cells. (C) 2019 Published by Elsevier B.V.en_US
dc.description.sponsorshipTechnological and Scientific Research Council of Turkey TUBITAK [3001(118R045)]en_US
dc.description.sponsorshipThis work was supported by the Technological and Scientific Research Council of Turkey TUBITAK -3001(118R045). Anti-proliferative activity studies were conducted at Sivas Cumhuriyet University Advanced Technology Application and Research Center (SCUTAM).en_US
dc.identifier.doi10.1016/j.molstruc.2019.126987
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85071413577en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2019.126987
dc.identifier.urihttps://hdl.handle.net/11616/98930
dc.identifier.volume1199en_US
dc.identifier.wosWOS:000492858500044en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Heterocyclic carbeneen_US
dc.subjectSilver complexen_US
dc.subjectAntiproliferative activityen_US
dc.subjectBreast canceren_US
dc.subjectProstate canceren_US
dc.titleSynthesis, characterization, and investigation of antiproliferative activity of novel Ag (I)-N-Heterocyclic Carbene (NHC) compoundsen_US
dc.typeArticleen_US

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