Differential expression of inflammasome regulatory transcripts in periodontal disease

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dc.authoridAral, Kubra/0000-0003-4798-4548
dc.authoridAral, Cüneyt Asım/0000-0002-7366-345X;
dc.authorwosidKapila, Yvonne/AAG-5418-2021
dc.authorwosidAral, Kubra/R-3039-2017
dc.authorwosidAral, Cüneyt Asım/AAA-3641-2020
dc.authorwosidAral, Cüneyt Asım/ABG-8668-2020
dc.contributor.authorAral, Kubra
dc.contributor.authorBerdeli, Eynar
dc.contributor.authorCooper, Paul Roy
dc.contributor.authorMilward, Michael Robert
dc.contributor.authorKapila, Yvonne
dc.contributor.authorUnal, Beyza Karadede
dc.contributor.authorAral, Cuneyt Asim
dc.date.accessioned2024-08-04T20:48:55Z
dc.date.available2024-08-04T20:48:55Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground The inflammasome modulates the release of key proinflammatory cytokines associated with periodontal disease pathogenesis. The aim of this study was to evaluate the expression of proteins that regulate the inflammasome, namely pyrin domain-only proteins (POPs), caspase activation recruitment domain (CARD)-only proteins, and tripartite motif-containing (TRIM) proteins, in periodontal diseases. Methods A total of 68 participants (34 males and 34 females) were divided into four groups, including periodontal health (H), gingivitis (G), chronic periodontitis (CP), and aggressive periodontitis (AgP) based on clinical parameters. Gingival tissue samples were obtained from all participants for reverse transcription polymerase chain reaction (RT-PCR)-based gene expression analyses of molecules that regulate the inflammasome, including apoptosis-associated speck-like protein (ASC) containing CARD, caspase-1, interleukin-1 beta (IL-1 beta), interleukin-18 (IL-18), nucleotide-binding domain, leucine rich family (NLR) pyrin domain containing 3 (NLRP3), NLR family pyrin domain containing 2 (NLRP2), AIM2 (absent in melanoma 2), POP1, POP2, CARD16, CARD18, TRIM16, and TRIM20 by RT-PCR. Results NLRP3 and IL-1 beta were upregulated in the G, CP, and AgP groups compared with group H (P < 0.05). AIM2 was downregulated in the CP group compared with the H, G, and AgP groups (P < 0.05). TRIM20, TRIM16, and CARD18 were downregulated in the G, CP, and AgP groups compared with the H group (P < 0.05). POP1 and POP2 were downregulated in the CP and AgP, and AgP and G groups, respectively (P < 0.05). Conclusion Active periodontal disease may result in downregulation of inflammasome regulators that may increase the activity of NLRP3 and IL-1 beta in periodontal disease.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK), Ankara, Turkeyen_US
dc.description.sponsorshipThis study was not supported by any financial organization. The corresponding author of this study (Kubra Aral) was supported with a scholarship by the Scientific and Technological Research Council of Turkey (TUBITAK), Ankara, Turkey. The authors report no conflicts of interest related to this study.en_US
dc.identifier.doi10.1002/JPER.19-0222
dc.identifier.endpage616en_US
dc.identifier.issn0022-3492
dc.identifier.issn1943-3670
dc.identifier.issue5en_US
dc.identifier.pmid31557327en_US
dc.identifier.scopus2-s2.0-85091036388en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage606en_US
dc.identifier.urihttps://doi.org/10.1002/JPER.19-0222
dc.identifier.urihttps://hdl.handle.net/11616/99544
dc.identifier.volume91en_US
dc.identifier.wosWOS:000490511100001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcaspase activation and recruitment domainsen_US
dc.subjectinflammasomesen_US
dc.subjectperiodontal diseaseen_US
dc.subjectpyrin domainen_US
dc.subjecttripartite motif proteinsen_US
dc.titleDifferential expression of inflammasome regulatory transcripts in periodontal diseaseen_US
dc.typeArticleen_US

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