The beneficial effects of nerolidol and hesperidin on surgically induced endometriosis in a rat model

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dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorCiftci, Osman
dc.contributor.authorEraslan, Sevil
dc.contributor.authorCetin, Asli
dc.contributor.authorBasak, Nese
dc.date.accessioned2024-08-04T20:44:28Z
dc.date.available2024-08-04T20:44:28Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe objective of this article is to analyze the effects of nerolidol and hesperidin treatment on surgically induced endometriosis in a rat model. Endometriosis was induced in 24 healthy adult female Wistar albino rats via homologous uterine horn transplantation. Three operations were performed on each rat. After the second operation, the rats were randomized into control, nerolidol, and hesperidin treatment groups, and medications were administered for 2 weeks. The effects of the drugs on the endometriotic foci were evaluated after the third operation. Compared with the endometriosis control group, the average volume of the lesions was significantly lower in rats treated with hesperidin and nerolidol. Malondialdehyde levels were significantly reduced in the nerolidol-treated group, and glutathione levels and superoxide dismutase activity were significantly elevated in the endometriotic foci of both the hesperidin- and nerolidol-treated groups compared with the endometriosis group. Hesperidin and nerolidol treatment also improved histological parameters, such as hemorrhage, vascular congestion, necrosis, and inflammatory cell infiltration in the endometriotic foci. The results of this study demonstrated that treatment with the potent antioxidants nerolidol and hesperidin caused a significant regression of surgically induced endometriotic foci in rats.en_US
dc.identifier.doi10.1080/09513590.2018.1469611
dc.identifier.endpage980en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue11en_US
dc.identifier.pmid29734842en_US
dc.identifier.scopus2-s2.0-85046629781en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage975en_US
dc.identifier.urihttps://doi.org/10.1080/09513590.2018.1469611
dc.identifier.urihttps://hdl.handle.net/11616/98271
dc.identifier.volume34en_US
dc.identifier.wosWOS:000452225200014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-inflammatory agentsen_US
dc.subjectendometriosisen_US
dc.subjecthesperidinen_US
dc.subjectnerolidolen_US
dc.subjectoxidative stressen_US
dc.titleThe beneficial effects of nerolidol and hesperidin on surgically induced endometriosis in a rat modelen_US
dc.typeArticleen_US

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