Synthesis and antimicrobial properties of cycloheptyl substituted benzimidazolium salts and their silver(I) carbene complexes

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dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authoridALICI, Bulent/0000-0001-5009-3223
dc.authoridKarataş, Mert Olgun/0000-0001-8500-2088
dc.authorwosidGünal, Selami/AAA-7246-2021
dc.authorwosidALICI, Bulent/AAG-4203-2019
dc.authorwosidKarataş, Mert Olgun/ABG-7848-2020
dc.contributor.authorKaratas, Mert Olgun
dc.contributor.authorGunal, Selami
dc.contributor.authorMansur, Ahmet
dc.contributor.authorAlici, Bulent
dc.contributor.authorCetinkaya, Engin
dc.date.accessioned2024-08-04T20:42:51Z
dc.date.available2024-08-04T20:42:51Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDue to increasing infections caused by microbes, there is an urgent need for the development of new effective antimicrobial agents. Silver-N-heterocyclic carbene (silver-NHC) complexes are a new class of antimicrobial agents. In this study, we aimed to synthesize highly lipophilic silver-NHC complexes. Four new complexes were synthesized by the reaction of the corresponding benzimidazolium salts and Ag2O in dichloromethane at room temperature. The synthesized compounds were characterized by H-1 NMR, C-13 NMR, IR and elemental analysis. The antimicrobial performances of benzimidazolium salts and silver complexes were tested against the standard bacterial strains Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and the fungi Candida albicans and Candida tropicalis. Minimum inhibitory concentrations (MICs) of all compounds were determined. The obtained data demonstrate that all benzimidazolium salts and silver complexes inhibit the growth of bacteria and fungi. Silver complexes are more active than the corresponding benzimidazolium salts (MIC: 6.25 mu g/mL for Gram-positive bacteria and fungi).en_US
dc.identifier.doi10.1515/hc-2016-0105
dc.identifier.endpage361en_US
dc.identifier.issn0793-0283
dc.identifier.issn2191-0197
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85002788408en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage357en_US
dc.identifier.urihttps://doi.org/10.1515/hc-2016-0105
dc.identifier.urihttps://hdl.handle.net/11616/97618
dc.identifier.volume22en_US
dc.identifier.wosWOS:000389640000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofHeterocyclic Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantimicrobialen_US
dc.subjectbenzimidazoleen_US
dc.subjectcycloheptylen_US
dc.subjectN-heterocyclic carbineen_US
dc.subjectsilveren_US
dc.titleSynthesis and antimicrobial properties of cycloheptyl substituted benzimidazolium salts and their silver(I) carbene complexesen_US
dc.typeArticleen_US

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