Risk factors for fecal carriage of extended-spectrum beta-lactamase-producing and carbapenem-resistant Escherichia coli and Klebsiella pneumoniae strains among patients at hospital admission

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dc.authoridBERK CAM, Hande/0000-0002-2820-1731;
dc.authorwosidBERK CAM, Hande/JRY-9895-2023
dc.authorwosidYAKUPOGULLARI, YUSUF/F-3966-2011
dc.authorwosidKizilates, Filiz/AAD-8022-2019
dc.contributor.authorKizilates, Filiz
dc.contributor.authorYakupogullari, Yusuf
dc.contributor.authorBerk, Hande
dc.contributor.authorOztoprak, Nefise
dc.contributor.authorOtlu, Baris
dc.date.accessioned2024-08-04T20:48:55Z
dc.date.available2024-08-04T20:48:55Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Extended-spectrum beta-lactamase (ESBL)-producing and carbapenem-resistant (CR) Enterobacteriaceae are substantial problems in hospital-acquired infections worldwide. We analyzed the risk factors for fecal carriage of ESBL-positive and/or CR E. coli and K. pneumoniae (EcKp) strains in a hospital in Turkey, an endemic country for both resistances. Materials and Methods: A prospective cross-sectional study including the rectal swab samples of 168 patients, obtained at the day of admission, was conducted. ESBL-producing and CR EcKp were investigated with phenotypic tests and PCR, and the clonal relatedness of isolates was studied. Risk analysis was performed with logistic regression method. Results: A total of 67 (39.8%) and 21 (12.5%) patient samples tested positive for ESBL-producing and CR EcKp, respectively. CTX-M (n = 27) and OXA-48 (n = 12) were the dominant ESBL and carbapenemase types, and 4.5%-10.7% of the isolates were clonally-related. Among 15 potential risk factors studied, longer lengths of hospital stay and antimicrobial use, and receiving total parenteral nutrition in the last 6 months were determined as independent risk factors for fecal carriage of ESBL-producing and/or CR EcKp, while prior antimicrobial treatment was only a risk factor for ESBL producers. Conclusion: Certain conditions in patients' medical backgrounds may be associated with increased likelihood of resistant bacterial colonization. Notably, questioning these situations at admission can help to identify potential carriers and proactively administer appropriate infection control measures. (C) 2020 Published by Elsevier Inc. on behalf of Association for Professionals in Infection Control and Epidemiology, Inc.en_US
dc.identifier.doi10.1016/j.ajic.2020.07.035
dc.identifier.endpage339en_US
dc.identifier.issn0196-6553
dc.identifier.issn1527-3296
dc.identifier.issue3en_US
dc.identifier.pmid32763346en_US
dc.identifier.scopus2-s2.0-85090849470en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage333en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajic.2020.07.035
dc.identifier.urihttps://hdl.handle.net/11616/99537
dc.identifier.volume49en_US
dc.identifier.wosWOS:000621804900009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMosby-Elsevieren_US
dc.relation.ispartofAmerican Journal of Infection Controlen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectESBLen_US
dc.subjectEnterobacteriaceaeen_US
dc.subjectIntestinal colonizationen_US
dc.subjectRisk analysisen_US
dc.titleRisk factors for fecal carriage of extended-spectrum beta-lactamase-producing and carbapenem-resistant Escherichia coli and Klebsiella pneumoniae strains among patients at hospital admissionen_US
dc.typeArticleen_US

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