Protective effects of resveratrol on salivary gland damage induced by total body irradiation in rats

dc.authoridGurocak, Asc Prof Simay/0000-0002-3707-5183
dc.authoridSIMSEK, GOKCE/0000-0001-5281-0986
dc.authoridKaradag Soylu, Nese/0000-0002-6303-5484
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridkaya pepele, eda/0000-0002-9193-0961
dc.authorwosidGurocak, Asc Prof Simay/N-3351-2014
dc.authorwosidSIMSEK, GOKCE/F-1019-2016
dc.authorwosidKaradag Soylu, Nese/ABH-9544-2020
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.authorwosidkaya pepele, eda/HGE-0700-2022
dc.contributor.authorSimsek, Gokce
dc.contributor.authorGurocak, Simay
dc.contributor.authorKaradag, Nese
dc.contributor.authorKarabulut, Aysun Bay
dc.contributor.authorDemirtas, Erol
dc.contributor.authorKaratas, Erkan
dc.contributor.authorPepele, Eda
dc.date.accessioned2024-08-04T20:36:16Z
dc.date.available2024-08-04T20:36:16Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives/Hypothesis: One of the most common acute side effects of irradiation is xerostomia, which results from damage to the salivary gland cells by direct ionization. Resveratrol is a natural compound with profound anti-inflammatory and antioxidant properties. The purpose of the present study was to investigate the potential protective effects of resveratrol on injury to the salivary glands of rats that were exposed to total body irradiation. Study Design: An experimental study at the Inonu University School of Medicine. Methods: Twenty-nine female rats were randomized into four groups: group 1, high-dose (100 mg/kg) resveratrol group (n = 7); group 2, low-dose (10 mg/kg) resveratrol group (n = 7); group 3, control (vehicle) rats (n = 7); and group 4, sham-irradiation group (n = 8). The medications were administered as single doses, and the rats were exposed to total body irradiation 24 hours after the treatment. The animals were sacrificed the following day, and the parotid and submandibular glands were excised. Salivary gland histology and the tissue levels of glutathione (GSH), nitric oxide (NO), and malondialdehyde (MDA) were investigated. Results: The rats in group 1 showed significantly decreased acinar loss and less ductal damage and cell necrosis than those of the control group (P < .05). Antioxidant GSH levels were significantly increased by high doses of resveratrol treatment. The tissue activities of MDA in both the parotid and submandibular glands were significantly reduced in group 1. Low-dose resveratrol treatment did not significantly alter the tissue levels of MDA. Conclusions: Resveratrol at relatively high doses can reduce the irradiation-dependent salivary gland damage, suggesting that this natural antioxidant may be effectively used to lessen the side effects related to salivary gland dysfunction that is induced by irradiation. Laryngoscope, 2012en_US
dc.identifier.doi10.1002/lary.23609
dc.identifier.endpage2748en_US
dc.identifier.issn0023-852X
dc.identifier.issue12en_US
dc.identifier.pmid23096936en_US
dc.identifier.scopus2-s2.0-84871273461en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2743en_US
dc.identifier.urihttps://doi.org/10.1002/lary.23609
dc.identifier.urihttps://hdl.handle.net/11616/95891
dc.identifier.volume122en_US
dc.identifier.wosWOS:000312540000023en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofLaryngoscopeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRadiationen_US
dc.subjectsalivary glanden_US
dc.subjectresveratrolen_US
dc.subjectoxidative stressen_US
dc.titleProtective effects of resveratrol on salivary gland damage induced by total body irradiation in ratsen_US
dc.typeArticleen_US

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